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Antimicrobial resistance profiles of vancomycin-resistant Enterococcus species isolated from laboratory mice


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Title: Antimicrobial resistance profiles of vancomycin-resistant Enterococcus species isolated from laboratory mice
Authors: Yamanaka, Hitoki / Kadomatsu, Ryuki / Takagi, Toshikazu / Ohsawa, Makiko / Yamamoto, Naoto / Kubo, Noriaki / Takemoto, Takahira / Ohsawa, Kazutaka
Issue Date: 15-Mar-2019
Publisher: Korean Society of Veterinary Science
Citation: Journal of veterinary science, 20(2), e13; 2019
Abstract: Isolates of 24 enterococci, 5 Enterococcus casseliflavus and 19 Enterococcus gallinarum, possessing vanC genes and showing low-level resistance to vancomycin were obtained from mice from commercial mouse breeding companies. Since some of these isolates showed resistance to other antibiotics, the purpose of this study was to clarify the resistant profiles of these isolates. One E. casseliflavus isolate showed resistance to erythromycin with a minimal inhibitory concentration (MIC) of 8 μg/mL and also showed apparent resistance to fluoroquinolones with an MIC of 32 μg/mL for ciprofloxacin. The MICs of 2 other fluoroquinolone-resistant E. casseliflavus and E. gallinarum isolates were 3 and 6 μg/mL, respectively. These 3 resistant isolates showed an absence of macrolide- and fluoroquinolone-resistant genes, including amino acid substitutions in the quinolone resistance determining regions of DNA gyrase and topoisomerase IV. Resistance to tetracycline was detected in 2 E.gallinarum isolates that were highly resistant, exhibiting MICs of 48 and 64 μg/mL and possessing tet(O) genes.The results indicate that antibiotic-resistant enterococci are being maintained in some laboratory mouse strains that have never been treated with an antibiotic.
Keywords: Antibiotic resistance / Enterococcus / laboratory mice
URI: http://hdl.handle.net/10069/39176
ISSN: 1229845X
DOI: 10.4142/jvs.2019.20.e13
Rights: © 2019 The Korean Society of Veterinary Science (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/39176

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