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BINOL-derived bifunctional sulfide catalysts for asymmetric synthesis of 3,3-disubstituted phthalides via bromolactonization


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Title: BINOL-derived bifunctional sulfide catalysts for asymmetric synthesis of 3,3-disubstituted phthalides via bromolactonization
Authors: Okada, Megumi / Kaneko, Kazuma / Yamanaka, Masahiro / Shirakawa, Seiji
Issue Date: 21-Apr-2019
Publisher: Royal Society of Chemistry
Citation: Organic and Biomolecular Chemistry, 17(15), pp.3747-3751; 2019
Abstract: An efficient enantioselective synthesis of 3,3-disubstituted phthalides possessing a chiral quaternary carbon center was achieved via catalytic asymmetric bromolactonization that utilized BINOL-derived bifunctional sulfide catalysts. Transformations of the bromo group in optically active phthalide products were also performed to demonstrate the utility of this novel synthetic protocol.
URI: http://hdl.handle.net/10069/39180
ISSN: 14770520
DOI: 10.1039/C9OB00417C
Rights: © 2019 The Royal Society of Chemistry.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/39180

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