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Central nervous system post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: The Nagasaki transplant group experience


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Title: Central nervous system post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: The Nagasaki transplant group experience
Authors: Sakamoto, Hikaru / Itonaga, Hidehiro / Taguchi, Jun / Kato, Takeharu / Sawayama, Yasushi / Hayashi, Tomayoshi / Baba, Shiro / Moriuchi, Masako / Ohshima, Koichi / Yoshida, Shinichiro / Moriuchi, Yukiyoshi / Miyazaki, Yasushi
Issue Date: 22-Apr-2019
Publisher: Elsevier Ltd.
Citation: Leukemia Research Reports, 11, pp.27-30; 2019
Abstract: A 17-year-old male received allogeneic transplantation for acute lymphoblastic leukemia, and presented with generalized seizures due to a solitary brain lesion with massive necrosis on day +621. Epstein–Barr virus (EBV) DNA copies were below the cut-off value in plasma. Stereotactic biopsy of the cerebral lesion confirmed the diagnosis of post-transplant lymphoproliferative disorder (PTLD) with large atypical cells positive for CD20 and EBER.In order to diagnose primary central nervous system PTLD, the biopsy should be applied as early as possible when brain lesion with necrosis develops in post-transplant patients regardless of EBV-DNA in plasma.
Keywords: Allogeneic hematopoietic stem cell transplantation / Central nervous system / Epstein–Barr virus / Post-transplant lymphoproliferative disorder
URI: http://hdl.handle.net/10069/39184
ISSN: 22130489
DOI: 10.1016/j.lrr.2019.04.003
Rights: © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/39184

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