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Successful outcome of second allogeneic bone marrow transplantation for blastic plasmacytoid dendritic cell neoplasm with MYC locus rearrangement


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Title: Successful outcome of second allogeneic bone marrow transplantation for blastic plasmacytoid dendritic cell neoplasm with MYC locus rearrangement
Authors: Kato, Takeharu / Itonaga, Hidehiro / Taguchi, Jun / Makiyama, Junya / Fujioka, Machiko / Taguchi, Masataka / Horai, Makiko / Sawayama, Yasushi / Niino, Daisuke / Imaizumi, Yoshitaka / Hata, Tomoko / Yoshida, Shinichiro / Sakamoto, Kana / Takeuchi, Kengo / Ohshima, Koichi / Miyazaki, Yasushi
Issue Date: 22-Apr-2019
Publisher: Elsevier Ltd.
Citation: Leukemia Research Reports, 11, pp.31-33; 2019
Abstract: A 62-year-old male was diagnosed with blastic plasmacytoid dendritic cell neoplasm (BPDCN) with a MYC rearrangement. Four months after the first unrelated bone marrow transplantation (BMT), he developed the relapsed BPDCN. After the achievement of partial remission following re-induction therapy, he underwent a second BMT from another unrelated donor, and experienced complete remission with grade II acute graft-versus-host disease and moderate chronic graft-versus-host disease. He remains alive in complete remission more than 71 months after the second BMT. These results suggested that donor change at the second transplantation may represent a considerable therapeutic option for patients with relapsed BPDCN.
Keywords: Allogeneic hematopoietic stem cell transplantation / Blastic plasmacytoid dendritic cell neoplasm / donor change / MYC rearrangement
URI: http://hdl.handle.net/10069/39185
ISSN: 22130489
DOI: 10.1016/j.lrr.2019.04.005
Rights: © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/39185

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