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Short stature-related single-nucleotide polymorphism (SNP) activates endothelial repair activity in elderly Japanese


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Title: Short stature-related single-nucleotide polymorphism (SNP) activates endothelial repair activity in elderly Japanese
Authors: Shimizu, Yuji / Yamanashi, Hirotomo / Noguchi, Yuko / Koyamatsu, Jun / Nagayoshi, Mako / Kiyoura, Kairi / Fukui, Shoichi / Tamai, Mami / Kawashiri, Shin-Ya / Arima, Kazuhiko / Maeda, Takahiro
Issue Date: 1-May-2019
Publisher: BioMed Central Ltd.
Citation: Environmental Health and Preventive Medicine, 24(1), art.no.26; 2019
Abstract: Background: Hypertension and atherosclerosis are bidirectionally related, while platelet count could serve as an indicator of endothelial repair. Therefore, high platelet counts could be associated with hypertension by indicating more intense endothelial repair activity. Furthermore, short stature has been shown to constitute a risk of atherosclerosis. Since inflammation-related single-nucleotide polymorphism (SNP(rs3782886)) is reportedly associated with myocardial infarction and short stature, rs3782886 could be associated with a high platelet count and thus more intense endothelial repair activity. Methods: We conducted a cross-sectional study of 988 elderly Japanese who participated in a general health check-up. Short stature was defined as a height of at or under the 25th percentile of the study population, and high platelet count as the highest tertiles of the platelet levels. Results: High platelet counts were found to be independently and positively associated with hypertension while rs3782886 was independently associated with high platelet levels and short stature. The classical cardiovascular risk factor-adjusted odds ratio (OR) and 95% confidence interval (CI) of high platelet count for hypertension was 1.34 (1.02, 1.77). With non-minor homo of the rs3782886 as the reference group, the adjusted OR and 95% CI for high platelet count and short stature of minor home were 2.40 (1.30, 4.42) and 2.21 (1.16, 4.21), respectively. Conclusion: SNP (rs3782886) was shown to be associated with high platelet count and short stature. This result partly explains how a genetic factor can influence the impact of height on endothelial repair.
Keywords: Height / Hypertension / Platelets / rs3782886 / SNP
URI: http://hdl.handle.net/10069/39204
ISSN: 1342078X
DOI: 10.1186/s12199-019-0780-1
Rights: © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/39204

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