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Evaluation of the targeted delivery of 5-fluorouracil and ascorbic acid into the brain with ultrasound-responsive nanobubbles


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Title: Evaluation of the targeted delivery of 5-fluorouracil and ascorbic acid into the brain with ultrasound-responsive nanobubbles
Other Titles: 超音波応答性ナノバブルを用いた5-フルオロウラシルとアスコルビン酸の脳内送達の評価
Authors: 三浦, 雄介
Authors (alternative): Miura, Yusuke
Issue Date: 20-Mar-2019
Publisher: Taylor & Francis
Citation: Nagasaki University (長崎大学), 博士(薬学) (2019-03-20)
Abstract: Recently, ultrasound-induced drug delivery into the brain using bubble formulations has been developed. After the brain delivery, however, the information on pharmacokinetics of hydrophilic drugs in the brain is lacking. In this study, to clarify the time-course pharmacokinetics of hydrophilic drugs, we used a brain microdialysis method. Using ultrasound-responsive nanobubbles (bubble liposomes (BLs)) with ultrasound irradiation, two hydrophilic drugs, 5-fluorouracil (5-FU) and ascorbic acid, were delivered into the brain of mice and rats and their time-course pharmacokinetics were evaluated with microdialysis. The results indicated that the time-course pharmacodynamics of ascorbic acid evaluated by examining its antioxidant capacity supported the time-course pharmacokinetics. Additionally, to strengthen the evidences of our evaluation, we varied the effect of BLs dose and duration and intensity of ultrasound irradiation on drug delivery. Among them, when the dose of BLs was changed, the trend of 5-FU intracerebral migration was consistent with other report. In conclusion, we succeeded in clarifying the time-course pharmacokinetics of the two hydrophilic drugs after the brain delivery with bubble formulations and ultrasound irradiation using mice and rats.
Description: 長崎大学学位論文 学位記番号:博(医歯薬)甲第1147号 学位授与年月日:平成31年3月20日
Keywords: Drug delivery system / ultrasound / bubble liposomes / blood-brain barrier / brain microdialysis
URI: http://hdl.handle.net/10069/39272
ISSN: 1061186X
DOI: 10.1080/1061186X.2017.1419354
Relational Links: http://hdl.handle.net/10069/39036
Rights: © 2017 Informa UK Limited
Type: Thesis or Dissertation
Text Version: ETD
Appears in Collections:dissertation

Citable URI : http://hdl.handle.net/10069/39272

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