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Periodontal Disease in Patients Receiving Dialysis

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Title: Periodontal Disease in Patients Receiving Dialysis
Authors: Miyata, Yasuyoshi / Obata, Yoko / Mochizuki, Yasushi / Kitamura, Mineaki / Mitsunari, Kensuke / Matsuo, Tomohiro / Ohba, Kojiro / Mukae, Hiroshi / Nishino, Tomoya / Yoshimura, Atsutoshi / Sakai, Hideki
Issue Date: 3-Aug-2019
Publisher: MDPI
Citation: International Journal of Molecular Sciences, 20(15), art.no.3805; 2019
Abstract: Chronic kidney disease (CKD) is characterized by kidney damage with proteinuria, hematuria, and progressive loss of kidney function. The final stage of CKD is known as end-stage renal disease, which usually indicates that approximately 90% of normal renal function is lost, and necessitates renal replacement therapy for survival. The most widespread renal replacement therapy is dialysis, which includes peritoneal dialysis (PD) and hemodialysis (HD). However, despite the development of novel medical instruments and agents, both dialysis procedures have complications and disadvantages, such as cardiovascular disease due to excessive blood fluid and infections caused by impaired immunity. Periodontal disease is chronic inflammation induced by various pathogens and its frequency and severity in patients undergoing dialysis are higher compared to those in healthy individuals. Therefore, several investigators have paid special attention to the impact of periodontal disease on inflammation-, nutrient-, and bone metabolism-related markers; the immune system; and complications in patients undergoing dialysis. Furthermore, the influence of diabetes on the prevalence and severity of manifestations of periodontal disease, and the properties of saliva in HD patients with periodontitis have been reported. Conversely, there are few reviews discussing periodontal disease in patients with dialysis. In this review, we discuss the available studies and review the pathological roles and clinical significance of periodontal disease in patients receiving PD or HD. In addition, this review underlines the importance of oral health and adequate periodontal treatment to maintain quality of life and prolong survival in these patients.
Keywords: Diabetes / Hemodialysis / Immune response / Periodontal disease / Peritoneal dialysis
URI: http://hdl.handle.net/10069/39429
DOI: 10.3390/ijms20153805
Rights: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/39429

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