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Oral surgery in patients with antiphospholipid syndrome


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Title: Oral surgery in patients with antiphospholipid syndrome
Authors: Okuyama, Kohei / Naruse, Tomofumi / Yutori, Hirokazu / Yanamoto, Souichi / Umeda, Masahiro
Issue Date: 28-Aug-2019
Publisher: Nihon University School of Dentistry / 日本大学歯学部
Citation: Journal of oral science, 61(3), pp.386-390; 2019
Abstract: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by recurrent thrombosis, other associated autoimmune disease, and/or obstetrical morbidity along with persistent production of antiphospholipid antibodies. Because of the nature of this systemic disease, most patients are medicated with antithrombotic agents and abundant glucocorticoids. This study reports a cohort of 16 patients with APS, who underwent oral surgery between 2010 and 2017 at the Nagasaki University Hospital. Because oral antithrombotic therapy was continued in the perioperative period, all wounds were strictly closed by suturing to prevent postoperative bleeding. Perioperative laboratory dates and medications were assessed. All patients achieved local postoperative hemostasis and did not exhibit systemic complications. Moreover, there were no postoperative systemic and/or local infections. Oral surgeons should suture oral wounds and ensure local hemostasis to prevent postoperative bleeding. Because patients with APS are likely to develop thrombosis despite continued administration of antithrombotic medications, strict perioperative examination of blood coagulation is needed. Furthermore, it is important to consider the damage and stress caused due to oral surgery. Moreover, when necessary, glucocorticoid therapy should be carefully administered, in accordance with the degree of invasion and judgment of the attending physician.
Keywords: antiphospholipid syndrome / oral surgery / antithrombotic medication / glucocorticoid / postoperative local hemostasis / collagen
URI: http://hdl.handle.net/10069/39444
ISSN: 13434934
DOI: 10.2334/josnusd.18-0164
Rights: © 2019 by Nihon University School of Dentistry
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/39444

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