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Production of a New Cyclic Depsipeptide by the Culture Broth of Staphylococcus sp. Isolated from Corallina officinalis L.


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Title: Production of a New Cyclic Depsipeptide by the Culture Broth of Staphylococcus sp. Isolated from Corallina officinalis L.
Authors: Abdelhameed, Reda F. A. / Elhady, Sameh S. / Noor, Ahmad O. / Almasri, Diena M. / Bagalagel, Alaa A. / Maatooq, Galal T. / Khedr, Amgad I. M. / Yamada, Koji
Issue Date: 11-Nov-2019
Publisher: MDPI
Citation: Metabolites, 9(11), art.no.273; 2019
Abstract: A new cyclic depsipeptide (1) has been isolated from culture broth of Staphylococcus sp. (No. P-100826-4-6) derived from Corallina officinalis L., together with the known compounds indol-3-carboxylic acid (2), 1,5-dideoxy-3-C-methyl arabinitol (3), thymine (4), uracil (5), cyclo (L-pro-L-omet) (6) and macrolactin B (7). The structure of (1) was established to be cyclo (2α, 3-diaminopropoinc acid-L-Asn-3-β-hydroxy-5-methyl-tetradecanoic acid-L-Leu1-L-Asp-L-Val-L-Leu2-L-Leu3) by extensive spectroscopic techniques including1 H NMR,13 C NMR,1 H-1 H COSY, HMBC, HSQC, NOESY, and HRFABMS. The antimicrobial activities of compounds 1–7 were evaluated. Compounds 1–5, and 7 showed moderate antimicrobial activity while compound 6 exhibited a potent antimicrobial and antifungal activities.
Keywords: Corallina o cinalis / Staphylococcus sp / cyclic depsipeptide / antimicrobial assay
URI: http://hdl.handle.net/10069/39557
DOI: 10.3390/metabo9110273
Rights: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/39557

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