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Re-emergence of dengue virus serotype 3 infections in Gabon in 2016–2017, and evidence for the risk of repeated dengue virus infections


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Title: Re-emergence of dengue virus serotype 3 infections in Gabon in 2016–2017, and evidence for the risk of repeated dengue virus infections
Authors: Abe, Haruka / Ushijima, Yuri / Loembe, Marguerite M. / Bikangui, Rodrigue / Nguema-Ondo, Georgelin / Mpingabo, Patrick I. / Zadeh, Vahid R. / Pemba, Christelle M. / Kurosaki, Yohei / Igasaki, Yui / de Vries, Sophia G. / Grobusch, Martin P. / Agnandji, Selidji T. / Lell, Bertrand / Yasuda, Jiro
Issue Date: 7-Dec-2019
Publisher: Elsevier Ltd
Citation: International Journal of Infectious Diseases, 91, pp.129-136; 2020
Abstract: Objectives: Dengue outbreaks, mainly caused by dengue virus serotype 2 (DENV-2), occurred in 2007 and in 2010 in Gabon, Central Africa. However, information on DENV infections has been insufficient since 2010. The aim of this study was to investigate the current DENV infection scenario and the risk of repeated infections in Gabon. Methods: During 2015–2017, serum samples were collected from enrolled febrile participants and were tested for DENV infection using RT-qPCR. DENV-positive samples were analyzed for a history of previous DENV infection(s) using ELISA. The complete DENV genome was sequenced to analyze the phylogeny of Gabonese DENV strains. Results: DENV-3 was exclusively detected, with a high rate of anti-DENV IgG seropositivity among DENV-3-positive participants. DENV-3 showed higher infection rates in adults and the infection was seasonal with peaks in the rainy seasons. Phylogenetic analysis revealed that Gabonese DENV-3 originated from West African strains and has been circulating continuously in Gabon since at least 2010, when the first DENV-3 case was reported. Conclusions: These findings indicate stable DENV-3 circulation and the risk of repeated DENV infections in Gabon, highlighting the need for continuous monitoring to control DENV infections.
Keywords: Africa / Dengue / Dengue virus / Gabon / Phylogeny / Surveillance
URI: http://hdl.handle.net/10069/39610
ISSN: 12019712
DOI: 10.1016/j.ijid.2019.12.002
Rights: © 2019 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/39610

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