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Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System


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Title: Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System
Authors: Satoh, Katsuya / Fuse, Takayuki / Nonaka, Toshiaki / Dong, Trong / Takao, Masaki / Nakagaki, Takehiro / Ishibashi, Daisuke / Taguchi, Yuzuru / Mihara, Ban / Iwasaki, Yasushi / Yoshida, Mari / Nishida, Noriyuki
Issue Date: 16-Dec-2019
Publisher: MDPI
Citation: Molecules, 24(24), art.no.4601; 2019
Abstract: Human prion diseases are neurodegenerative disorders caused by prion protein. Although infectivity was historically detected only in the central nervous system and lymphoreticular tissues of patients with sporadic Creutzfeldt-Jakob disease, recent reports suggest that the seeding activity of Creutzfeldt-Jakob disease prions accumulates in various non-neuronal organs including the liver, kidney, and skin. Therefore, we reanalyzed autopsy samples collected from patients with sporadic and genetic human prion diseases and found that seeding activity exists in almost all digestive organs. Unexpectedly, activity in the esophagus reached a level of prion seeding activity close to that in the central nervous system in some CJD patients, indicating that the safety of endoscopic examinations should be reconsidered.
Keywords: prion / rt-quic
URI: http://hdl.handle.net/10069/39611
DOI: 10.3390/molecules24244601
Rights: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/39611

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