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Postoperative coagulation profiles of patients undergoing adult-to-adult living donor liver transplantation—A single-center experience

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Title: Postoperative coagulation profiles of patients undergoing adult-to-adult living donor liver transplantation—A single-center experience
Authors: Ichinomiya, Taiga / Murata, Hiroaki / Sekino, Motohiro / Sato, Shuntaro / Higashijima, Ushio / Matsumoto, Shuhei / Ishizaki, Hironori / Yoshitomi, Osamu / Maekawa, Takuji / Eguchi, Susumu / Hara, Tetsuya
Issue Date: 23-Dec-2019
Publisher: Elsevier Inc.
Citation: Transplantation Reports, 5(1), art.no.100037; 2020
Abstract: Objective: To characterize the pre- and postoperative coagulation profiles of patients undergoing adult-to-adult living donor liver transplantation (LDLT), using various coagulation tests and rotational thromboelastometry (ROTEM). Methods: This single-center observational study evaluated the various coagulation profiles of 22 patients (13 men and 9 women). Blood samples were obtained immediately after the induction of anesthesia (PRE) and on postoperative days (PODs) 1, 3, 5, and 7 after LDLT surgery. Results: Most procoagulant factors (fibrinogen, platelet, and coagulation factors II, VII, VIII, and IX) improved to levels equal to or greater than the PRE levels on POD 7. The levels of von Willebrand factor significantly increased after surgery, whereas those of disintegrin-like and metalloproteinase with thrombospondin type 1 motif 13 decreased. Although the thrombin-antithrombin III complex increased immediately after surgery, the plasmin-α 2 plasmin inhibitor complex increased only on POD 7. The level of plasminogen activator inhibitor-1 increased on POD 1, returning to PRE levels on POD 3. Almost all ROTEM parameters were decreased or prolonged, compared to the PRE levels, on POD 7. Conclusions: The values of most coagulation tests showed the improvement or acceleration of coagulability on POD 7 than at PRE, with almost all the ROTEM parameters decreased or prolonged. Therefore, it cannot be concluded whether ROTEM reflects the net effect of hemostatic balance after liver transplantation.
Keywords: Living donor liver transplantation / Postoperative hemostatic balance / Rotation thromboelastometry / Coagulation test / Hypercoagulability
URI: http://hdl.handle.net/10069/39615
ISSN: 24519596
DOI: 10.1016/j.tpr.2019.100037
Rights: © 2019 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/BY-NC-ND/4.0/).
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/39615

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