DSpace university logo mark
Advanced Search
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > Institute of Tropical Medicine > Articles in academic journal >

CD4+ T Responses Other Than Th1 Type Are Preferentially Induced by Latency-Associated Antigens in the State of Latent Mycobacterium tuberculosis Infection

File Description SizeFormat
fimmu10_2807.pdf1.58 MBAdobe PDFView/Open

Title: CD4+ T Responses Other Than Th1 Type Are Preferentially Induced by Latency-Associated Antigens in the State of Latent Mycobacterium tuberculosis Infection
Authors: Yamashita, Yoshiro / Oe, Toshiyuki / Kawakami, Kenji / Osada-Oka, Mayuko / Ozeki, Yuriko / Terahara, Kazutaka / Yasuda, Ikkoh / Edwards, Tansy / Tanaka, Takeshi / Tsunetsugu-Yokota, Yasuko / Matsumoto, Sohkichi / Ariyoshi, Koya
Issue Date: 29-Nov-2019
Publisher: Frontiers Media S.A.
Citation: Frontiers in Immunology, 10, art.no.2807; 2019
Abstract: Mycobacterium tuberculosis (M. tuberculosis) produces a diverse range of antigenic proteins in its dormant phase. The cytokine profiles of CD4+ T cell responses, especially subsets other than Th1 type (non-Th1 type), against these latency-associated M. tuberculosis antigens such as α-crystallin (Acr), heparin-binding hemagglutinin (HBHA), and mycobacterial DNA-binding protein 1 (MDP-1) remain elusive in relation to the clinical stage of M. tuberculosis infection. In the present study, peripheral blood mononuclear cells (PBMCs) collected from different stages of M. tuberculosis-infected cases and control PBMCs were stimulated with these antigens and ESAT-6/CFP-10. Cytokine profiles of CD4+ T cells were evaluated by intracellular cytokine staining using multicolor flow cytometry. Our results demonstrate that Th1 cytokine responses were predominant after TB onset independent of the type of antigen stimulation. On the contrary, non-Th1 cytokine responses were preferentially induced by latency-associated M. tuberculosis antigens, specifically IL-10 response against Acr in latent M. tuberculosis infection. From these results, we surmise a shift in the CD4+ T cell response from mixed non-Th1 to Th1 dominant type during TB progression.
Keywords: Acr / CD4+ T cells / HBHA / latent M / tuberculosis infection / MDP-1non-Th1
URI: http://hdl.handle.net/10069/39619
DOI: 10.3389/fimmu.2019.02807
Rights: © 2019 Yamashita, Oe, Kawakami, Osada-Oka, Ozeki, Terahara, Yasuda, Edwards, Tanaka, Tsunetsugu-Yokota, Matsumoto and Ariyoshi. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/39619

All items in NAOSITE are protected by copyright, with all rights reserved.


Valid XHTML 1.0! Copyright © 2006-2015 Nagasaki University Library - Feedback Powerd by DSpace