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Correlation between vertebral bone microstructure and estimated strength in elderly women: An ex-vivo HR-pQCT study of cadaveric spine


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Title: Correlation between vertebral bone microstructure and estimated strength in elderly women: An ex-vivo HR-pQCT study of cadaveric spine
Other Titles: 高齢女性における椎体の骨強度を規定する骨微細構造因子の検討:HR-pQCTによる全脊椎のex vivo解析
Authors: 山田, 周太
Authors (alternative): Yamada, Shuta
Issue Date: 19-Mar-2020
Publisher: Elsevier Inc.
Citation: Nagasaki University (長崎大学), 博士(医学) (2020-03-19)
Abstract: Purpose: A vertebral fracture is the most common complication of osteoporosis, and various factors are involved in its occurrence. The purpose of this study was to investigate the role of trabecular and cortical bone microstructure on vertebral strength using high-resolution peripheral quantitative computed tomography (HR-pQCT). Methods: Three female cadaveric spines were investigated (average age: 80.3 years). The whole spine (T1-L4) was scanned by second-generation HR-pQCT at a voxel size of 60.7 μm. Bone microstructure analysis and micro finite element analysis were performed after excluding the upper and lower endplates and posterior elements of a total of 48 vertebrae. Correlations between trabecular and cortical bone microstructure parameters and estimated vertebral strength were analyzed by univariate and multivariate regression models. Results: Cortical thickness (Ct.Th) and trabecular thickness (Tb.Th) were strongly correlated with estimated failure load on univariate analysis (r = 0.89, 0.82). Trabecular volumetric bone mineral density (Tb.vBMD), bone volume fraction (BV/TV), trabecular number (Tb.N), and Ct.Th were correlated with estimated failure load on multivariate regression analysis. Conclusions: It was suggested that, in addition to trabecular bone (Tb.vBMD, BV/TV, Tb.N), cortical bone (Ct.Th) contributed significantly to vertebral strength in elderly women.
Description: 長崎大学学位論文 学位記番号:博(医歯薬)甲第1220号 学位授与年月日:令和2年3月19日 / Author: Shuta Yamada, Ko Chiba, Narihiro Okazaki, Makoto Era, Yuichiro Nishino, Kazuaki Yokota, Akihiko Yonekura, Masato Tomita, Toshiyuki Tsurumoto, Makoto Osaki / Citation: Bone, 120, pp.459-464; 2019
Keywords: High-resolution peripheral quantitative / computed tomography (HR-pQCT) / Bone microstructure / Estimated bone strength / Vertebral body
URI: http://hdl.handle.net/10069/39731
ISSN: 87563282
DOI: 10.1016/j.bone.2018.12.005
Relational Links: http://hdl.handle.net/10069/39918
Rights: © 2018 Elsevier Inc. All rights reserved.
Type: Thesis or Dissertation
Text Version: ETD
Appears in Collections:dissertation

Citable URI : http://hdl.handle.net/10069/39731

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