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Thymus and Activation-regulated Chemokine as a Biomarker for IgG4-related Disease


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Title: Thymus and Activation-regulated Chemokine as a Biomarker for IgG4-related Disease
Authors: Umeda, Masataka / Origuchi, Tomoki / Kawashiri, Shin-ya / Koga, Tomohiro / Ichinose, Kunihiro / Furukawa, Kaori / Sato, Tomohito / Tsuji, Sousuke / Endo, Yushiro / Takatani, Ayuko / Shimizu, Toshimasa / Fukui, Shoichi / Iwamoto, Naoki / Igawa, Takashi / Tamai, Mami / Nakamura, Hideki / Kawakami, Atsushi
Issue Date: 7-Apr-2020
Publisher: Springer Nature
Citation: Scientific reports, 10(1), art.no.6010; 2020
Abstract: High serum concentrations of thymus and activation-regulated chemokine (TARC) are observed in allergic diseases such as atopic dermatitis and bronchial asthma. Frequent allergic symptoms have been reported in patients with IgG4-related disease (IgG4-RD). We investigated the pathogenic role of TARC as a biomarker in IgG4-RD patients. We evaluated the serum concentrations of TARC from 29 IgG4-RD patients, 28 primary Sjögren syndrome (pSS) patients, and 23 healthy controls (HCs) by enzyme-linked immunosorbent assay (ELISA). We analyzed the correlations between the TARC concentrations and the subjects’ clinical parameters. To investigate the biological effect of TARC on the pathogenesis of IgG4-RD, we evaluated the in vitro induction of plasmablasts from IgG4-RD patients by TARC. The serum concentrations of TARC in the IgG4-RD patients were significantly higher than those of the pSS patients and HCs. The serum TARC concentration of the IgG4-RD group was positively correlated with the IgG4-RD responder index (IgG4-RD RI) score and with the number of organs involved, but it was not correlated with the serum IgG4 level or eosinophil number in the IgG4-RD patients’ peripheral blood. The patients who had lung involvement had higher serum TARC concentrations. In vitro, TARC clearly induced the formation of plasmablasts from the IgG4-RD patients’ peripheral blood mononuclear cells. Collectively, our data suggest that a systemic increment of TARC may contribute to the development of IgG4-RD through an aberrant induction of plasmablasts.
URI: http://hdl.handle.net/10069/39887
DOI: 10.1038/s41598-020-62941-9
Rights: © 2020, The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/39887

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