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Behçet's Disease with Severe Autonomic Disorders Developing after Herpes Zoster


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Title: Behçet's Disease with Severe Autonomic Disorders Developing after Herpes Zoster
Authors: Koto, Serina / Umeda, Masataka / Kawano, Hiroaki / Endo, Yushiro / Shimizu, Toshimasa / Koga, Tomohiro / Ichinose, Kunihiro / Nakamura, Hideki / Mukaino, Akihiro / Higuchi, Osamu / Nakane, Shunya / Kawakami, Atsushi
Issue Date: 15-Apr-2020
Publisher: The Japanese Society of Internal Medicine / 日本内科学会
Citation: Internal Medicine, 59(8), pp.1099-1104; 2020
Abstract: A 58-year-old Japanese woman with herpes zoster developed Behçet's disease (BD) with symptoms including orthostatic intolerance as an autonomic disorder. Multiple immune-suppressive therapies and a β-blocker successfully controlled both the disease activity of BD and the autonomic disorders. A cytokine multiplex analysis of her serum revealed the elevation of proinflammatory cytokines [interleukin (IL)-1, IL-6, IL-12, tumor necrosis factor alfa (TNFα), and interferon gamma (IFN-γ)] and a low IL-10 concentration. IL-10 production is reported to be important for defense against herpes zoster virus (VZV). Insufficient IL-10 production is reported in BD. The reactivation of VZV with this cytokine profile suggests that BD will develop with various symptoms, including severe autonomic disorders.
Keywords: Autonomic disorder / Behçet's disease / Herpes zoster / IL-10
URI: http://hdl.handle.net/10069/39980
ISSN: 09182918
DOI: 10.2169/internalmedicine.3954-19
Rights: © 2020 The Japanese Society of Internal Medicine. The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/39980

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