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Secondary Pulmonary Alveolar Proteinosis Following Treatment with Azacitidine for Myelodysplastic Syndrome


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Title: Secondary Pulmonary Alveolar Proteinosis Following Treatment with Azacitidine for Myelodysplastic Syndrome
Authors: Hashimoto, Miki / Itonaga, Hidehiro / Nannya, Yasuhito / Taniguchi, Hirokazu / Fukuda, Yuichi / Furumoto, Takafumi / Fujioka, Machiko / Kasai, Sachie / Taguchi, Masataka / Taniguchi, Hiroaki / Sato, Shinya / Sawayama, Yasushi / Atogami, Sunao / Iwasaki, Keisuke / Hata, Tomoko / Soda, Hiroshi / Moriuchi, Yukiyoshi / Nakata, Koh / Ogawa, Seishi / Miyazaki, Yasushi
Issue Date: 20-Apr-2020
Publisher: The Japanese Society of Internal Medicine / 日本内科学会
Citation: Internal Medicine, 59(8), pp.1081-1086; 2020
Abstract: Secondary pulmonary alveolar proteinosis (sPAP) is a complication of myelodysplastic syndrome (MDS). A 60-year-old woman was diagnosed with MDS with excess blasts-1. Fifty-four months after the initial diagnosis, treatment with azacitidine was initiated. Seventy-three months after the diagnosis, a bone marrow examination revealed increased myeloblasts, at which time computed tomography showed diffuse ground-glass opacities and interlobular septal thickening in the bilateral lower lung fields. A lung biopsy revealed the presence of PAP; therefore, the clinical diagnosis of MDS/sPAP was confirmed. Careful attention should be paid to the development of sPAP in MDS patients with pulmonary lesions during azacitidine treatment.
Keywords: myelodysplastic syndromes / secondary pulmonary alveolar proteinosis / azacitidine / umbilical cord blood transplantation
URI: http://hdl.handle.net/10069/39981
ISSN: 09182918
DOI: 10.2169/internalmedicine.3770-19
Rights: © 2020 The Japanese Society of Internal Medicine. The Internal Medicine is an Open Access journal distributed under license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/39981

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