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Title: 日本脳炎の血清疫学的研究
Other Titles: Serological Study of Japanese Encephalitis
Authors: 川副, 広俊
Authors (alternative): Kawasoe, Hirotoshi
Issue Date: 25-Mar-1967
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 9(1). p1-14, 1967
Abstract: With the cases of Japanese encephalitis at the time of its epidemic in Nagasaki prefecture as an objet, this research has been carried on in order to clarify the phase of its active prevalence by confirming the cases through serological and virological methods and also to clear the infiltration of Japanese encephalitis virus by investigation the condition of antibodies carried by the prefectural people, obtaining the results as follows: 1) As the result of serum diagnosis carried out in 1964 of 31 from among 57 reported cases of Japanese encephalitis, 11 cases were confirmed. In 1955, 33 cases were confirmed as the result of serum diagnosis made of 70 out of 86 reported cases of Japanese encephalitis. In addition, in 1965, from among the persons who were reported to be the cases of Japanese encephalitis and yet who were negatived as the result of serum diagnosis, some were confirmed to have been suffering from aseptic meningitis caused by ECHO 4, Cox. B1 and B5 virus respectively. 2) In consequence of the investigation into HI antibody holding in serum carried out in 1964 of 714 persons in normal health in various parts of Nagasaki prefecture, the positivity proved amounting to 35.3%, the antibody titer showing 1:10-1:80 in most cases. As to the rate of positivity, when classified according to three age groups, the highest one was found in the advanced aged group with the early aged group ranking next, and the lowest in the rising generation group. After the epidemic period of Japanese encephalitis, the rate of positivity was increased by about 8%. 3) In 1965, with 566 primary school children as an object, investigation into HI antibody holding value in serum was carried out in May and November, before and after the epidemic period of Japanese encephalitis, for the purpose of clarifying the change in the value as to each child. Out of 65 children who had not been vaccinated, 3 children who had not have antibody in May were found having antibody titer of 1:10 or 1:20 in November for the first time and a child was found showing increase by 4 times in his antibody holding value. This fact is considered to have been caused by inapparent infection of Japanese encephalitis virus during summer in 1965. As to 501 children who had been vaccinated, the rate of their positivity showed 9.1% increase from 22.8% in May to 31.9% in November. It was also revealed that the antibody holding value in November was generally higher than in May. In addition, the antibody holding condition of those children in each primary school showed different phases according to the location and environment of the three primary schools.
URI: http://hdl.handle.net/10069/4004
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 9, No. 1

Citable URI : http://hdl.handle.net/10069/4004

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