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Co-delivery Systems of Multiple Drugs Using Nanotechnology for Future Cancer Therapy


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Title: Co-delivery Systems of Multiple Drugs Using Nanotechnology for Future Cancer Therapy
Authors: Fumoto, Shintaro / Nishida, Koyo
Issue Date: 1-Jul-2020
Publisher: 日本薬学会 / Pharmaceutical Society of Japan
Citation: Chemical & pharmaceutical bulletin, 68(7), pp.603-612; 2020
Abstract: Cancer treatments have improved significantly during the last decade but are not yet satisfactory. Combination therapy is often administered to improve efficacy and safety. Drug delivery systems can also improve efficacy and safety. To control the spatiotemporal distribution of drugs, nanotechnology involving liposomes, solid lipid nanoparticles, and polymeric micelles has been developed. Co-delivery systems of multiple drugs are a promising approach to combat cancer. Synergistic effects and reduced side effects are expected from the use of co-delivery systems. In this review, we summarize various co-delivery systems for multiple drugs, including small-molecule drugs, nucleic acids, genes, and proteins. Co-delivery of drugs with different properties is relatively difficult, but some researchers have succeeded in developing such co-delivery systems. Environment-responsive carrier designs can control the release of cargos. Although their preparation is more complicated than that of mono-delivery systems, co-delivery systems can simplify clinical procedures and improve patient QOL.
Keywords: liposome / polymer / small-molecule drug / DNA / RNA / protein
URI: http://hdl.handle.net/10069/40144
ISSN: 00092363
DOI: 10.1248/cpb.c20-00008
Rights: © 2020 The Pharmaceutical Society of Japan
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/40144

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