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Undifferentiated carcinoma of the oral tongue treated with cetuximab: A case report

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Title: Undifferentiated carcinoma of the oral tongue treated with cetuximab: A case report
Authors: Sakamoto, Yuki / Yanamoto, Souichi / Adachi, Masaki / Tsuda, Shoma / Furukawa, Kohei / Naruse, Tomofumi / Umeda, Masahiro
Issue Date: 4-Feb-2019
Publisher: Spandidos Publications
Citation: Molecular and Clinical Oncology, 10(4), pp.446-450; 2019
Abstract: Undifferentiated carcinoma of the oral cavity is a rare and possibly fatal malignant neoplasm. We present here a case of undifferentiated carcinoma of the oral tongue, which responded well to chemotherapy with cisplatin, 5-fluorouracil, and cetuximab. A 59-year-old man was referred to our hospital for a large tumor of the tongue. Physical examination revealed an ulcerative tumor, approximately 50 mm in diameter, on the right edge of the tongue and swelling of multiple cervical lymph nodes; therefore, the clinical diagnosis was tongue cancer (T4aN2bM0). The histological diagnosis from a biopsy specimen was undifferentiated carcinoma; we tested the sample for human papilloma virus immunoreactivity, which was positive. The patient then underwent chemotherapy with cisplatin, 5-fluorouracil and cetuximab. The tumor’s size decreased markedly after two courses of chemotherapy, but the treatment was stopped due to the patient'various mental problems and pneumonia; he died 6 months after the initial visit. Our encounter with this patient suggests that cetuximab treatment is a good option for HPV-positive undifferentiated carcinoma of the oral tongue.
Keywords: 5-fluorouracil / Cetuximab / Cisplatin / Human papilloma virus / Oral tongue / Undifferentiated carcinoma
URI: http://hdl.handle.net/10069/40165
ISSN: 20499450
DOI: 10.3892/mco.2019.1808
Rights: © 2019, Spandidos Publications.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/40165

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