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Development of Multi-functional Nanoparticles for Clinical Application to Gene and Nucleic Acid Medicines


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Title: Development of Multi-functional Nanoparticles for Clinical Application to Gene and Nucleic Acid Medicines
Authors: Sasaki, Hitoshi
Issue Date: 1-Aug-2020
Publisher: 日本薬学会 / The Pharmaceutical Society of Japan
Citation: Biological & pharmaceutical bulletin, 43(8), pp.1147-1153; 2020
Abstract: Gene and nucleic medicines have recently gained attention as novel drugs with the advancement of molecular biology and genetics; however, they have low bioavailability and low target delivery due to their low stability and poor membrane permeability. Therefore, the development of an effective drug delivery system (DDS) is necessary for the practical use of gene and nucleic acid medicines;however, despite considerable research, both safety and efficiency remain poor. Furthermore, the healthcare needs are not met by traditional DDS. Therefore, we developed an effective multi-functional DDS, which is constructed using materials that are safe for human consumption. This DDS involves several ternary complexes as novel gene delivery carriers constructed by coating the cationic complex of the gene and nucleic acid medicines as well as the biodegradable cationic polymer with a biocompatible anionic polymer.Early implementation of the ternary complex in clinical studies is expected due to their efficacy and safety. Furthermore, these complexes may be prepared using large-scale manufacturing. In addition, personalized DDS may be prepared according to the patient's disease stage, which is useful for advanced therapy.
Keywords: gene / nucleic acid / gene delivery / nanoparticle / ternary complex
URI: http://hdl.handle.net/10069/40208
ISSN: 09186158
DOI: 10.1248/bpb.b20-00156
Rights: © 2020 The Pharmaceutical Society of Japan
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/40208

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