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Human T-cell lymphotropic virus type-1 infection associated with sarcopenia: community-based cross-sectional study in Goto, Japan


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Title: Human T-cell lymphotropic virus type-1 infection associated with sarcopenia: community-based cross-sectional study in Goto, Japan
Authors: Yamanashi, Hirotomo / Nobusue, Kenichi / Nonaka, Fumiaki / Honda, Yukiko / Shimizu, Yuji / Kawashiri, Shin-Ya / Izumida, Mai / Kubo, Yoshinao / Tamai, Mami / Nagata, Yasuhiro / Yanagihara, Katsunori / Kulkarni, Bharati / Kinra, Sanjay / Kawakami, Atsushi / Maeda, Takahiro
Issue Date: 24-Jul-2020
Publisher: Impact Journals LLC
Citation: Aging, 12(15), pp.15504-15513; 2020
Abstract: Sarcopenia is characterized by a progressive skeletal muscle disorder that involves the loss of muscle mass and low muscle strength, which contributes to increased adverse outcomes. Few studies have investigated the association between chronic infection and sarcopenia. This study aimed to examine the association between human T-cell lymphotropic virus type-1 (HTLV-1) and sarcopenia. We conducted a cross-sectional study and enrolled 2,811 participants aged ≥ 40 years from a prospective cohort study in Japanese community dwellers during 2017-2019. Sarcopenia was defined as low appendicular skeletal muscle mass and low handgrip strength. The association between HTLV-1 seropositivity and sarcopenia was assessed using multivariable logistic regression. Odds ratio (OR) and 95% confidence interval (CI) of sarcopenia were analysed using HTLV-1 seropositivity.We adjusted for age, sex, body mass index, physical activity, systolic blood pressure, glycated haemoglobin, low-density lipoprotein cholesterol, and smoking and drinking status. Of 2,811 participants, 484 (17.2%) HTLV-1 infected participants were detected. HTLV-1 infection was significantly associated with sarcopenia (adjusted OR 1.46, 95% CI 1.03-2.07, P = 0.034). HTLV-1 was associated with sarcopenia among community-dwelling adults.Active surveillance and early detection of asymptomatic HTLV-1 infection might be beneficial to reinforce countermeasures to inhibit the progress of HTLV infection-associated sarcopenia.
Keywords: Appendicular skeletal muscle mass / Chronic inflammation / Handgrip strength / HTLV-1 / Sarcopenia
URI: http://hdl.handle.net/10069/40238
DOI: 10.18632/aging.103736
Rights: © Yamanashi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License(CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/40238

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