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Toxoplasma gondiiの生物学的研究 : 第3報 Toxoplasma gondiiのマウスにおける経口および経皮感染実験


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Title: Toxoplasma gondiiの生物学的研究 : 第3報 Toxoplasma gondiiのマウスにおける経口および経皮感染実験
Other Titles: Biological Studies on Toxoplasma gondii : III. Examination on Oral and Percutaneous Infections with Toxoplasma gondii in Mice
Authors: 本村, 一郎
Authors (alternative): Motomura, Ichiro
Issue Date: Dec-1967
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 9(4). p244-255, 1967
Abstract: Experimental infection with Toxoplasma gondii in mice was examined by the inoculation methods through mouth or injured skin, using the RH proliferative form and the Beverley cyst. The oral inoculation was performed by pouring the parasite emulsions into the stomach of mice with the syringe having a needle with a bluntly rounded end. For the cutaneous inoculation, both of the superficial and profound injuries of skin were artificially produced on the back of mice respectively by excoriating the skin surface with a piece of sand paper and by incising the skin deeply to the muscle stratum. The parasites emulsions were dropped to the surfaces of skin lesions. Results achieved were summarized as follows: 1) In the oral inoculation of parasites, it was demonstrated that the minimum infective dosage of proliferative forms was 10^3 and that even one cyst could be infective for mice. 2) In the inoculation of parasites through the superficial excoriation of skin, the minimum infective dosages of parasites were 15×10^3 proliferative forms and 2×102 cysts. While, through the profound incised lesion, 15×102 proliferative forms and 10 cysts were able to infect mice. No infection of mice with the parasites through the healthy skin could be observed in a control experiment.
URI: http://hdl.handle.net/10069/4024
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 9, No. 4

Citable URI : http://hdl.handle.net/10069/4024

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