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Group 2 Innate Lymphoid Cells Exacerbate Amebic Liver Abscess in Mice


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Title: Group 2 Innate Lymphoid Cells Exacerbate Amebic Liver Abscess in Mice
Authors: Nakamura, Risa / Yoshizawa, Akihiro / Moriyasu, Taeko / Deloer, Sharmina / Senba, Masachika / Kikuchi, Mihoko / Koyasu, Shigeo / Moro, Kazuyo / Hamano, Shinjiro
Issue Date: 25-Sep-2020
Publisher: Cell Press
Citation: iScience, 23 (9), art.no.101544; 2020
Abstract: Entamoeba histolytica, a protozoan parasite in the lumen of the human large intestine, occasionally spreads to the liver and induces amebic liver abscesses (ALAs). Upon infection with E. histolytica, high levels of type 2 cytokines are induced in the liver early after infection. However, the sources and functions of these initial type 2 cytokines in ALA formation remain unclear. In this study, we examined the roles of group 2 innate lymphoid cells (ILC2s) in ALA formation. Hepatic ILC2 numbers were significantly increased and they produced robust levels of IL-5. The in vivo transfer of ILC2s into Rag2−/−common γ chain (γc)−/− KO mice aggravated ALA formation accompanied by eosinophilia and neutrophilia. Furthermore, IL-33-deficient mice and IL-5-neutralized mice had less ALA formations. These results suggest that ILC2s contribute to exacerbating the pathogenesis of ALA by producing early type 2 cytokines and promoting the accumulation of eosinophils and neutrophils in the liver.
Keywords: Immunology / Microbiology / Microbiology Parasite
URI: http://hdl.handle.net/10069/40309
ISSN: 25890042
DOI: 10.1016/j.isci.2020.101544
Rights: ©2020 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/40309

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