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長崎県諌早地区におけるレプトスピラ病の潜在


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Title: 長崎県諌早地区におけるレプトスピラ病の潜在
Other Titles: Leptospirosis as an Endemic Disease in Isahaya Area, Nagasaki Prefecture, with Special Reference to the Existence of Subclinical Infection
Authors: 馬場, 宇一郎
Authors (alternative): Baba, U-Ichiro
Issue Date: 20-Feb-1970
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 11(4). p202-211, 1970
Abstract: In Nagasaki Prefecture, Hasami district had been regarded long as the main endemical focus of the disease. The affairs, however, have changed in the last twenty or thirty years, and it is presumable by this clinical and sero-epidemiological study that the disease has been distributed moredensely in the coastal area of Isahaya Bay than in Hasami. Among 66 cases that carry a history of fever, jaundice and the characteristic ophthalmological sequelae if not all, 16(24.3%) were found positive by agglutination-lysis tests using six leptospira type cultures at the serum dilution of 1:80 or higher. They were divided as follows: 8 to L. hebdomadis, 5 to L. australis A, 2 to L. autumnalis, and one each to L. icterohaemorrhagiae and L. pyrogenes. On the other hand, there could be detected 15(5.0%) serological positive cases among 303 cases of both patients of other diseases and healthy bodies. The type distribution in this group, that is, 7 L. hebdomadis, 3 L. autumnalis, two each L. australis A and L. pyrogenes, and one L. icterohaemorrhagiae, was alike on the whole to that in the mentioned patient group with the anamnesis. On the basis of this resemblance, together with a close relationship in geographical distribution of L. hebdomadis-positive cases between the two groups, the author proposes an opinion that the positive sero-reaction in the latter group is attributable to subclinical infection due to any leptospira type at one time. / 長崎県波佐見地方は長くレプトスピラ病の主要な発生地として知られていた.しかるにこの2,30年間に事情が大いに変り,この臨床および血清疫学的研究によって,諌早市を中心に有明湾の最奥部に臨む沿岸地帯に,波佐見地方以上の密度に本病が分布していることが推知された.発熱,黄疸と特異な眼後遺症(いずれかを缺ぐものも含めて)の既往歴があるもの66例のうち,6種の標準レプトスピラ培養についての凝集溶菌反応が80倍以上陽性なものが16例(24.3%)あった.内訳すればL. hebdomadisに対するもの8例,L. australis A 5例,L. autumnalis 2例,L. icterohaemorrhagiaeとL. pyrogenes各1例であった.一方,他病患者と健康者303例の検査では15例(5.0%)が血清反応陽性を示した.その型別はL. hebdomadis 7例,L. autumnalis 3例,L. australis AとL. pyrogenes各2例,L. icterohaemorrhagiae1例で,その成積は上記「有症」群によく似ているといえよう.この類似性と,両群のL. hebdomadis陽性例が地理的分布上密接な関係を示していることを考慮に入れて,後者すなわち「無症」群での血清反応陽性例は,ある時期においていずれかのレにより不顕性感染を起したものと考案した.
URI: http://hdl.handle.net/10069/4062
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 11, No. 4

Citable URI : http://hdl.handle.net/10069/4062

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