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Tamaoki's Antigen Factor S1; Its Distribution among Cholera Vibrio Strains and Significance of Its Existence

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Title: Tamaoki's Antigen Factor S1; Its Distribution among Cholera Vibrio Strains and Significance of Its Existence
Other Titles: 玉置の抗原因子S1,そのコレラ菌における分布と存在意義
Authors: Horikawa, Hiro-oki
Authors (alternative): 堀川, 広興
Issue Date: 15-Dec-1970
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 12(3). p128-141, 1970
Abstract: The antigen factor S1 which is of a K-antigen nature has been distributed, regardless either of the known O-antigens or of the rough variation by conventional criteria, among classical cholera vibrios, but not among El Tor vibrios. For preparation of accurate diagnostic sera for Inaba and Ogawa serotypes, care should be taken of the existence of this accessory factor. This factor was demonstrable in a soluble state by complement fixation, and the antibody against it took part in the vibriocidal activity. The strain sensitive to complement, irrespective of degree, was found only among the strains carrying this antigen. In the light of this point, the S1-positive strain seems regarded as "semirough" mutant appeared in the course of long-term storage. This strain was less virulent to the mouse than the S1-lacking one, but there was no difference among the strains in the vaccine effectiveness whether they possess S1 or not. / 抗原因子S1はK抗原としての性状をもち,既知O抗原ともまた通例の形態・理化学判定規準によるR型変異とも関係なく,クラシックコレラ菌株に分布しているがエルトールコレラ菌株には分布していない.稲葉,小川血清型別用の正確な困子血清を調製するに当ってはこの附加因子の存在に顧慮を要する.本因子は補体結合反応で溶性の形で立証でき,また本因子に対する抗体は殺ビブリオ性に関與していた.程度の差こそあれ補体に対し感受性を示す菌株は本抗原を有していた.この点からみると,S1陽性菌は菌株の長期保存中に発現したセミR変異菌とみなしえるようである.この菌株はS1欠のものよりマウスに対する毒力が低いが,一方,ワクチン効果については免疫原のS1の有無によって差異を認めなかった.
URI: http://hdl.handle.net/10069/4078
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 12, No. 3

Citable URI : http://hdl.handle.net/10069/4078

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