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Diethylcarbamazineのバンクロフト糸状虫仔虫の末梢血内出現性に及ぼす影響


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Title: Diethylcarbamazineのバンクロフト糸状虫仔虫の末梢血内出現性に及ぼす影響
Other Titles: Effect of Diethylcarbamazine on Microfilarial Rhythm of W. bancrofti
Authors: 岩本, 功
Authors (alternative): Iwamoto, Isao
Issue Date: 15-Mar-1971
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 13(1). p1-6, 1971
Abstract: Katamine (1955) has already reported that diethylcarbamazine had a strong action to provoke the emigration of microfilaria into the peripheral blood even in the daytime beside the remarkable effect to kill microfilaria. However, the action mechanism is still unknown. In this paper, various small amounts of the drug were tested for its action. When 0.1 mg per kg or more was given orally to microfilaria carriers during daytime, microfilaria began to appear in the peripheral circulation within 5 minutes reaching its peak usually about 15 minutes after the administration. The minimum oral dose to arise the emigration of microfilaria may be around 0.1 mg per kg body weight, which is merely one-twentieth the usual clinical dose. When administration of 0.1 mg or 0.2 mg per kg of the drug, 4 times a day was continued for several days, there was found the emigration of larva during daytime increasing gradually in the number day by day in spite of no microfilariacidal effect was demonstrated. According to Fujimaki (1956), the minimum concentration of the drug effective to kill microfilaria in the blood is about 0.8 microgram per ml. For study of microfilarial periodicity, it will be very important evidence that presence of the small amount of diethylcarbamazine base in the blood which is not enough to kill microfilaria causes not only the temporary appearance of larva but also disturbance of the 24 hour microfilarial rhythm. / 著者はバンクロフト糸状虫仔虫の周期性の機序に関する研究の一環としてDECの仔虫誘出作用について観察を行った.1)仔虫の誘出作用の認められるDECの最少量は概ね0.1mg/kg前後にあり,それより以上の経口1回投与により著明な昼間仔虫の出現がみられ,15分乃至30分で最高値に達する.2)0.1乃至0.3mg/kgの小量を1日4回.連続して投与を続けると24時間内の仔虫数の総数には大きな滅少はないが,その翌日から次第に昼間の出現仔虫数が増加し,仔虫曲線は平担となり,周期性に乱れがみられる.即ちDECのきわめて微量が血中に存在することによって仔虫の周期性が敏感に影響を受ける.
URI: http://hdl.handle.net/10069/4085
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 13, No. 1

Citable URI : http://hdl.handle.net/10069/4085

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