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Evaluation of Effectiveness of Chemotherapy in Cholera

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タイトル: Evaluation of Effectiveness of Chemotherapy in Cholera
著者: Nakatomi, Masao
発行日: 1971年 3月15日
出版者: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
引用: 熱帯医学 Tropical medicine 13(1). p26-43, 1971
抄録: Chloramphenicol has recently been criticised as antibacterial drug for cholera because of probable inactivation in the body and appearance of resistant strains of Vibrio cholerae. In the present study, chloramphenicol was compared with dihydroxymethyl furalazine in regard to amount of diarrhea, reduction of vibrios in stool and the drug concentration in stool and blood. 1. With oral administration of chloramphenicol, neither reduction of vibrios nor elevation of drug level in stool were seen. 2. Two cases with intravenous administration of chloramphenicol revealed high concentration of the drug and marked reduce of vibrios in stool. 3. In all cases with oral administration of furalazine, effective concentration of the drug in stool was regularly found and at the same time, remarkable decrease of the number of vibrios was recognized. Moreover, it was observed that vibrios disappeared in stool in almost all cases, as the level of the drug showed further elevation. 4. An untoward reaction of furalazine, vomiting, was seen in one case. Furalazine can be recommended as a substitutional drug for treatment of cholera.
URI: http://hdl.handle.net/10069/4088
ISSN: 03855643
資料タイプ: Departmental Bulletin Paper
出現コレクション:第13巻 第1号

引用URI : http://hdl.handle.net/10069/4088



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