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Title: 抗トリコモナス剤の治療効果に関する実験的研究
Other Titles: Experimental Studies on the Effectiveness of Antitrichomonal Drugs against Trichomonas vaginalis
Authors: 李, 錦璋
Authors (alternative): Lee, Jien-Chang
Issue Date: 30-Jun-1972
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 14(2). p97-110, 1972
Abstract: The following 8 kinds of antitrichomonal drugs were examined in vitro for growth inhibiting effect upon 2 strains (S and H strains) of Trichomonas Vaginalis: 3 antibiotics (trichomycin, pimaricin, and azalomycin F) and 5 synthetic chemicals (carbarsone, chlordantoin, piperanitrozole, metronidazole and rimovazole). The parasites were inoculated in each tube containing the V-bouillon medium and different concentrations of drugs. After the incubation for 48 hours at 37℃, the numbers of active parasites were counted using Burker-Turk's haemacytometer, and the percentages of growthinhibition by the drugs were calculated by comparison with data in the control where no drug was added into the culture medium. The percentage data were transformed into Probit value to calculate a regression line for each strain and each drug. Then, 99.9% inhibiting dose (ID_<99・9>) and 50% inhibiting dose (ID_<50>) of the drugs were obtained from the regression lines. Among the drugs tested carbarsone and pimaricin had rather higher ID_<99・9> and ID_<50>, whereas trichomycin, piperanitrozole, metronidazole and nimovazole showed lower ID_<99・9> and ID_<50>. There were statistically no significant difference between the two strains tested in ID_<99・9> as well as ID_<50> for each drug. In vivo experiments were also carried out to examine the therapeutic effect of drugs against the experimental abscess-formation caused by the subcutaneous inoculation of Trichomonas vaginalis to the back of mice. After the parasite inoculation the following drugs were orally treated: trichomycin, piperanitrozole, metronidazole and nimovazole. Trichomycin showed unexpectedly low therapeutic effect against the abscessformation whereas it was highly toxic to mice. On the other hand, piperanitrozole, metronidazole and nimovazole showed noticeable therapeutic effect without toxicity at a dosage of 50mg/kg/day for 5 days.
URI: http://hdl.handle.net/10069/4116
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 14, No. 2

Citable URI : http://hdl.handle.net/10069/4116

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