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東アフリカ,ウガンダ国の主要食品類より分離された毒性真菌類


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Title: 東アフリカ,ウガンダ国の主要食品類より分離された毒性真菌類
Other Titles: Toxic Fungi Isolated from Uganda Foodstuffs A histopathological study of acute toxicity of fungal culture filtrates
Authors: 板倉, 英世 / 木下, 良順
Authors (alternative): Itakura, Hideyo / Kinosita, Riojun
Issue Date: 30-Aug-1975
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 17(2). p73-90, 1975
Abstract: 肝疾患が多発する東アフリカに於ける食品寄生真菌類の有毒性(Mycotoxin産生の有無)について検索した.ウガンダ国のほぼ全域に亘って日常主要食品類(落花生,米,豆類など)を収集し,各種の真菌類を分離培養して,その培養濾液をマウス(C3H/HeJ)に経口投与することによって短期間(数日~十数日)に生じる臓器障害を病理組織学的に調べた.検索した322 strainのうち209 strainが何らかの毒性を示し,Aspergillus及びPenicilliumがその多くを占めていた.障害を受けた臓器は肝をはじめ腎,膵,睾丸,胸腺,腸管及び腹膜などである.そのほか共同研究としてBacteriocidal effects,Fluorescent compounds, Kojic acidなどについても調べたので考察した. / For the detection of acute toxicity of possible unknown mycotoxins in culture filtrates of fungi which had been isolated from Uganda foodstuffs, short-term animal experiments were carried out using 4 to 6 weeks old C3H/HeJ male mice by the method of intraperitoneal injection. Out of 322 tested strains of fungi, 209 strains caused positive pathologic effects on mice. Among them, almost all the strains of Aspergillus (Asp.) niger, Asp. ochraceus, Asp. ostianus and Asp. ficuum, and many strains of Asp. flavus, Asp. oryzae, Asp. versicolor, Penicillium (Pen.) cyclopium, Pen. rubrum and Pen. funiculosum caused toxic effects on mice. The main pathological findings were restricted to the liver, kidney, pancreas, testis, thymus and peritoneum. Furthermore, the strains of fungi which showed strongly positive bacteriocidal effects, production of fluorescent compounds and kojic acid, respectively or together, caused positive pathologic effects on mice with the exception of a few strains and are considered to produce toxic metabolites in culture filtrates.
URI: http://hdl.handle.net/10069/4182
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 17, No. 2

Citable URI : http://hdl.handle.net/10069/4182

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