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韓国におけるサルモネラ,シゲラの抗菌剤耐性及びRプラスミッド


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Title: 韓国におけるサルモネラ,シゲラの抗菌剤耐性及びRプラスミッド
Other Titles: Drug Resistance and R Plasmids of Salmonella and Shigella in Korea
Authors: 全, 燾基 / 薛, 盛用
Authors (alternative): Chun, Doki / Seol, Sung Yong
Issue Date: 30-Jun-1978
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 20(2). p123-129, 1978
Abstract: 1973年から1977年までの5年間に韓国大邸地方で分離したサルモネラ及びシゲラについて実験した.最近,パラチフスA菌の感染例が増加の傾向を示している.分離したパラチフスA菌100株のうちクロラムフェニコール(Cm),テトラサイクリン(Tc),ストレプトマイシン(Sm),カナマイシン(Km)の4剤に耐性の1株を除く全菌株が,常用の抗菌剤に感受性であった.耐性株の耐性は非伝達性であった.腸チフスは地方病の様相を示し毎年多数の患者が発生している.総分離菌939株のうち耐性菌は5.3%で. Sm,スルフイソミヂン(Sa)の2剤耐性菌が最も多いが,その耐性度は弱かった.耐性伝達性の高度耐性菌は毎年数株ずつ検出されたが,最近減少の傾向を示している.これらの耐性株はCm, Tc, Sm, Sa,アンピシリン(Ap), Kmのうち4剤以上に耐性を有し, Cm, Tc, Sm, Saの4剤耐性株が最も多かった.プラスミッドとしてはR(Cm Tc Sm Sa), R (Ap Km), R (Cm)が検出された.赤痢患者は,病院を訪ずれる例が少ないので,検出菌株数は少数であった.99株が分離され,主にB, D群であったが,分離菌の約80%が抗菌剤耐性菌であった. Cm, Tc, Sm, Saの4剤耐性菌が最も多く, Ap耐性をともなうものも見られた.耐性菌の74.7%が,伝達性耐性であり,各菌の保有する全耐性が大腸菌に伝達された.4剤以上の耐性を有する菌の耐性伝達性は3剤以下の耐性菌の伝達性より頻繁に見られた. / Salmonella and Shigella isolated in Korea from 1973 to 1977 were tested for the resis-tance to drugs and for R plasmids. Only one (1.0%) strain of Salmonella paratyphi A was resistant to the four drugs, tetracycline (Tc), streptomycin (Sm), sulfisomidine (Sa) and kanamycin (Km). The resistance was not conjugative. Strains resistant to one or more drugs tested were 5.3% in S. typhi and 79.8% in Shigella. Among 50 drug-resistant S. typhi, 15 strains were multiply resistant to four or more of the drugs, chloramphenicol (Cm), Tc, Sm, Sa, ampicillin (Ap) and Km, and all fifteen of them transferred at least some of their resistances to E. coli ML 1410. Demonstrated R plasmids were R (Cm Tc Sm Sa), R (Ap Km) and R (Cm). Strains resistant to three or fewer drugs did not transfer the resistances. A majority of drug-resistant Shigella strains were resistant to three or more drugs. R plasmids were demonstrated in 74.7% of drug-resistant Shigella; these strains transferred their complete resistance patterns to E. coli. The R plasmids were more frequently observed among strains resistant to four or more drugs than those resistant to three or fewer drugs. Ap resistance was transferred independently of resistance to Cm, Tc, Sm and Sa in S. typhi, but was always transferred together with the other resistances in Shigella.
URI: http://hdl.handle.net/10069/4239
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 20, No. 2

Citable URI : http://hdl.handle.net/10069/4239

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