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ウェステルマン肺吸虫の抗原分析に関する研究 : 2.成虫分画抗原の免疫反応について


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Title: ウェステルマン肺吸虫の抗原分析に関する研究 : 2.成虫分画抗原の免疫反応について
Other Titles: Studies on the Antigenic Analysis in Paragonimus westermani. : 2. Observations on antibody response against fractionated antigens from adult-worm extract.
Authors: 今井, 淳一
Authors (alternative): Imai, Jun-Ichi
Issue Date: 31-Aug-1979
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 21(2). p45-55, 1979
Abstract: Experimental studies were conducted to elucidate the nature, development and changes in antibody response against gel filtration of fractionated and metabolic antigens in Paragonimus westermani infection of cat and human being. (1) Somatic antigen of adult worm was resolved into 6 fractions on Sephadex G-200 gel filtration of molecular weight ranging 30,000 to 700,000 daltons. (2) During infection, precipitin reaction was observed mainly against lower molecular weight fractions in Ouchterlony tests and immunoelectrophoresis, while it was against higher molecular weight fractions in immunized rabbit sera. Precipitin arcs were most numerous against fractions No.2, 3 and 4. (3) Metabolic antigen in worm sac behaved similarly to fractions No.4 and 5 in thin layer electrophoresis of polyacrylamide gel and the pattern was also similar in immunoelectrophoresis. (4) Consequently, precipitin against fractions No.3 and 4 were detected in the early stage and the titer reached its peak around 12-14 weeks of infection. Reaction to fraction No.4 was most numerous (100%) followed by fraction No.3 (88%) and No.5 (82%). Precipitin against fractions No.1 and 6 appeared in the late stage of infection.
URI: http://hdl.handle.net/10069/4251
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 21, No. 2

Citable URI : http://hdl.handle.net/10069/4251

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