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ウェステルマン肺吸虫の抗原分析に関する研究 : 2.成虫分画抗原の免疫反応について


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タイトル: ウェステルマン肺吸虫の抗原分析に関する研究 : 2.成虫分画抗原の免疫反応について
その他のタイトル: Studies on the Antigenic Analysis in Paragonimus westermani. : 2. Observations on antibody response against fractionated antigens from adult-worm extract.
著者: 今井, 淳一
著者(別表記) : Imai, Jun-Ichi
発行日: 1979年 8月31日
出版者: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
引用: 熱帯医学 Tropical medicine 21(2). p45-55, 1979
抄録: Experimental studies were conducted to elucidate the nature, development and changes in antibody response against gel filtration of fractionated and metabolic antigens in Paragonimus westermani infection of cat and human being. (1) Somatic antigen of adult worm was resolved into 6 fractions on Sephadex G-200 gel filtration of molecular weight ranging 30,000 to 700,000 daltons. (2) During infection, precipitin reaction was observed mainly against lower molecular weight fractions in Ouchterlony tests and immunoelectrophoresis, while it was against higher molecular weight fractions in immunized rabbit sera. Precipitin arcs were most numerous against fractions No.2, 3 and 4. (3) Metabolic antigen in worm sac behaved similarly to fractions No.4 and 5 in thin layer electrophoresis of polyacrylamide gel and the pattern was also similar in immunoelectrophoresis. (4) Consequently, precipitin against fractions No.3 and 4 were detected in the early stage and the titer reached its peak around 12-14 weeks of infection. Reaction to fraction No.4 was most numerous (100%) followed by fraction No.3 (88%) and No.5 (82%). Precipitin against fractions No.1 and 6 appeared in the late stage of infection.
URI: http://hdl.handle.net/10069/4251
ISSN: 03855643
資料タイプ: Departmental Bulletin Paper
出現コレクション:第21巻 第2号

引用URI : http://hdl.handle.net/10069/4251

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