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温度環境の担癌マウスに与える影響


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Title: 温度環境の担癌マウスに与える影響
Other Titles: The Effect of Ambient Temperature Conditions on the Mice Bearing Ehrlich Ascites Tumor
Authors: 山下, 裕人 / 鈴木, 康子 / 石井, 三和子 / 千馬, 正敬 / 真田, 文明 / 寺尾, 英夫 / 瀬戸口, 智彦 / 板倉, 英世
Authors (alternative): Yamashita, Hiroto / Suzuki, Yasuko / Ishii, Miwako / Senba, Masachika / Sanada, Fumiaki / Terao, Hideo / Setoguchi, Tomohiko / Itakura, Hideyo
Issue Date: 28-Dec-1979
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 21(4). p179-186, 1979
Abstract: The effect of different ambient temperature conditions on the survival days of mice bearing Ehrlich ascites tumor was studied. The ddY strain mice were innoculated the tumor intraperitoneally and kept at different thermal conditions. The conditions were 4℃, 15℃ and 30℃ in Exp. 1 and 4℃ for four days then 20℃ and 20℃ in Exp. 2. In Exp. 1, 5th-passaged-tumor and in Exp. 2, 22nd-passaged-tumor were used. In Exp. 1, the mice at low temperature conditions (4℃ and 15℃) lived longer than those at high temperature one (30℃). It took more than 20 days after the treatment for the survival effect of the low temperature conditions to be observed. The tumor of the mice at low temperature conditions showed solidification i.e., loss of liquidity and the Fisher exact probability test revealed that low temperature conditions promoted the solidification of the tumor. In the same low temperature conditions, the mouse which lived longer showed more prominent solidification of the tumor. Histologically, the solid tumor showed aggregation of tumor cells with little ascitic fluid. Focally, the contact of tumor cells was seen. The tumor cells showed marked degenerative change and low mitotic rate. Therefore, it was concluded that the solidification of the tumor was one of the main causes of the survival effect of the low temperature conditions. In Exp. 2, no difference was seen in survival days of two groups. But the statistical test also showed that the low temperature condition (4℃) promoted solidification of the tumor more than the middle temperature condition (20℃), and the mice of two groups were dead within 15 days after the treatment. It was concluded that in Exp. 2, the increased lethal effect of the tumor which had beenobtained during many passages surpassed the survival effect of the low temperature condition. These experiments suggest that the low temperature conditions such as 4℃ and 15℃ have the potentiality as anti-tumor agent. The relationship between the survival effect and solidification of the tumor in the low temperature conditions and cold adaptation mechanism was also discussed.
URI: http://hdl.handle.net/10069/4266
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 21, No. 4

Citable URI : http://hdl.handle.net/10069/4266

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