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サルモネラ症の化学療法に関する実験的研究 : 特にchloramphenicolの生体内における有効性について


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Title: サルモネラ症の化学療法に関する実験的研究 : 特にchloramphenicolの生体内における有効性について
Other Titles: Studies on the Antimicrobial Treatment of Experimental Salmonellosis : Effectiveness of Chloramphenicol in vivo and Its Mechanism
Authors: 林, 敏明 / 岩永, 正明
Authors (alternative): Hayashi, Toshiaki / Iwanaga, Masaaki
Issue Date: 30-Jun-1980
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 22(2). p89-94, 1980
Abstract: In the antimicrobial treatment of salmonellosis, especially typhoid fever, no drug is clinically superior to chloramphenicol, although antibacterial effect of chloramphenicol in vitro is most inferior to other drugs. These facts were confirmed again in the present study using salmonellosis in C_<57>BL mice challenged orally with Salmonella typhimurium. To clarify the reason why chloramphenicol is so beneficial in the treatment of salmonellosis, a comparative study on chloramphenicol and amoxicillin was carried out using the experimental animals, in regards to distribution and duration of their activity in vivo, and the influence to bactericidal activity of the normal human serum. No significant difference between two drugs was found as far as the above regards were concerned. However, multiplication of challenged salmonella in the organs was markedly inhibited by the presence of chloramphenicol even in low concentration.
URI: http://hdl.handle.net/10069/4277
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 22, No. 2

Citable URI : http://hdl.handle.net/10069/4277

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