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鉄負荷によるラット実験肝癌の抑制


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Title: 鉄負荷によるラット実験肝癌の抑制
Other Titles: The Inhibitory Effect of Iron-overload on the Chemically-induced Hepatocarcinogenesis in Rats.
Authors: 山下, 裕人 / 飯田, 芙佐枝 / 石井, 三和子 / 千馬, 正敬 / 板倉, 英世
Authors (alternative): Yamashita, Hiroto / Iida, Fusae / Ishii, Miwako / Senba, Masachika / Itakura, Hideyo
Issue Date: 30-Oct-1980
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 22(3). p173-180, 1980
Abstract: Effects of iron-overload on the chemically-induced carcinogenesis of the rat liver were studied. The rats were given 2% of ferric amonium citrate in drinking water for 3 weeks, usual drinking water for 1 week and then 50 ppm diethylnitrosamine. The rats of the control group were given usual drinking water for 4 weeks and then 50 ppm diethylnitrosamine. Each paired group composed of treated rats and control rats given diethylnitrosamine for the same period was sacrificed simultaneously at the different experimental periods. The hepatoma nodules and the size of each nodule were examined. Then the histopathological study of the liver was done. The comparison of the development of the hepatoma, estimated by the number and sizes of the nodules, were made in each paired group. Although 16 paired groups were tested, the comparison could be made only in 10 pairs. Nine pairs showed more developed hepatoma nodules in the control group than in the treated group and one pair showed the reversed result. Sign test was done and the calculated probability of the observed result was 0.0107. This result suggests that ironoverload inhibits the carcinogenicity of diethylnitrosamine in rats.
URI: http://hdl.handle.net/10069/4285
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 22, No. 3

Citable URI : http://hdl.handle.net/10069/4285

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