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慢性肝炎・肝硬変から肝細胞癌に至る発癌過程の肝実質細胞の病理形態


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Title: 慢性肝炎・肝硬変から肝細胞癌に至る発癌過程の肝実質細胞の病理形態
Other Titles: Histopathology of Liver Parenchymal Lesions Associated with Liver Cell Carcinoma in the Course of Chronic Viral Hepatitis
Authors: 瀬戸口, 智彦
Authors (alternative): Setoguchi, Tomohiko
Issue Date: 27-Dec-1980
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 22(4). p245-253, 1980
Abstract: Biopsy and autopsy specimens of the liver of chronic hepatitis, cirrhosis of the liver and liver cell carcinoma in the course of viral hepatitis were examined histopathologically to observe parenchymal lesions associated with liver cell carcinoma. Seventeen patients who had been initially diagnosed as chronic active hepatitis or cirrhosis of the liver by liver biopsy and finally diagnosed as liver cell carcinoma by surgical operation or post-mortem examination were studied. Several characteristic lesions of parenchymal cells of the liver were observed in chronic hepatitis and cirrhosis of the liver. The lesions were as follows: 1) liver cells showing pavement pattern, 2) atypical structural cells, 3) Anthony's liver cell dysplasia, and 4) small basophilic cells. Among the lesions, "small basophilic cells" were characteristic especially in precancerous stage of liver cell carcinoma. The size of liver cells of the lesion is relatively small, and the cytoplasm is moderately basophilic. These cells appeared, focally or in zonal pattern, at late stage of cirrhosis or chronic active hepatitis in which liver cell carcinoma eventually arised. However, it remains unclear whether "small basophilic cells" are precancerous lesion or not. Under electron microscopy, aggregation of mitochondria in perinuclear regions and proliferation of rough endoplasmic reticulum were noted. It seems that "small basophilic cells" are proliferative or regenrative cells.
URI: http://hdl.handle.net/10069/4291
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 22, No. 4

Citable URI : http://hdl.handle.net/10069/4291

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