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DEN誘発ラット肝癌発生に対する四塩化炭素の影響と肝葉別障害像の差異


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Title: DEN誘発ラット肝癌発生に対する四塩化炭素の影響と肝葉別障害像の差異
Other Titles: Effects of Carbon Tetrachloride (CCl_4) on Diethylnitrosamine (DEN)-induced Rat Hepatocellular Carcinoma : Different Susceptibility of Each Liver Lobe
Authors: 眞田, 文明
Authors (alternative): Sanada, Fumiaki
Issue Date: 30-Jun-1981
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 23(2). p91-104, 1981
Abstract: Effects of CCl_4 on rat hepatocellular carcinoma, which was induced by DEN, were studied morphologically. Administration of 100 ppm DEN in drinking water to rats for 8 weeks was followed by repeated subcutaneous injections of CCl_4 dissolved in olive oil (1:1, v/v), 0.1ml per 100g body weight, weekly. A group thus treated was compared with a group which was not given CCl_4 after administration of DEN. Although succesive treatment of CCl_4 exerted little influence on a latent period of carcinogenesis of DEN in the liver, increase of the number of carcinoma was noticed. The size of each carcinoma nodule was rather smaller than in the control group. Nodular hyperplasia developed in parallel with growth of carcinoma. It seemed that the period in which nodular hyperplasia turns into carcinoma was relatively short (probably 2 weeks). There is no mutual relation between developmernt of fibrosis and carcinogenesis. Susceptibility of rat liver lobes to DEN was greater in 4th, 5th and 6th lobes than 1st, 2nd and 3rd lobes. Fatty metamorphosis caused by CCl_4 was more marked in 1st, 2nd and 3rd lobes than in 4th, 5th and 6th lobes. On the contrary, fibrosis and other liver lesions were stronger in 4th, 5th and 6th lobes than in 1st, 2nd and 3rd lobes by the same agent. Variation of lesions might be explained by different distribution of the enzymes in liver lobes. However, it is also undeniable in this study that variation of lesions is a consequence of differences in distribution of venous drainage or arterial supply.
URI: http://hdl.handle.net/10069/4302
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 23, No. 2

Citable URI : http://hdl.handle.net/10069/4302

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