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DEN誘発ラット肝癌発生に対する四塩化炭素の影響と肝葉別障害像の差異


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タイトル: DEN誘発ラット肝癌発生に対する四塩化炭素の影響と肝葉別障害像の差異
その他のタイトル: Effects of Carbon Tetrachloride (CCl_4) on Diethylnitrosamine (DEN)-induced Rat Hepatocellular Carcinoma : Different Susceptibility of Each Liver Lobe
著者: 眞田, 文明
著者(別表記) : Sanada, Fumiaki
発行日: 1981年 6月30日
出版者: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
引用: 熱帯医学 Tropical medicine 23(2). p91-104, 1981
抄録: Effects of CCl_4 on rat hepatocellular carcinoma, which was induced by DEN, were studied morphologically. Administration of 100 ppm DEN in drinking water to rats for 8 weeks was followed by repeated subcutaneous injections of CCl_4 dissolved in olive oil (1:1, v/v), 0.1ml per 100g body weight, weekly. A group thus treated was compared with a group which was not given CCl_4 after administration of DEN. Although succesive treatment of CCl_4 exerted little influence on a latent period of carcinogenesis of DEN in the liver, increase of the number of carcinoma was noticed. The size of each carcinoma nodule was rather smaller than in the control group. Nodular hyperplasia developed in parallel with growth of carcinoma. It seemed that the period in which nodular hyperplasia turns into carcinoma was relatively short (probably 2 weeks). There is no mutual relation between developmernt of fibrosis and carcinogenesis. Susceptibility of rat liver lobes to DEN was greater in 4th, 5th and 6th lobes than 1st, 2nd and 3rd lobes. Fatty metamorphosis caused by CCl_4 was more marked in 1st, 2nd and 3rd lobes than in 4th, 5th and 6th lobes. On the contrary, fibrosis and other liver lesions were stronger in 4th, 5th and 6th lobes than in 1st, 2nd and 3rd lobes by the same agent. Variation of lesions might be explained by different distribution of the enzymes in liver lobes. However, it is also undeniable in this study that variation of lesions is a consequence of differences in distribution of venous drainage or arterial supply.
URI: http://hdl.handle.net/10069/4302
ISSN: 03855643
資料タイプ: Departmental Bulletin Paper
出現コレクション:第23巻 第2号

引用URI : http://hdl.handle.net/10069/4302

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