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X線照射による視床下部障害ウサギの体温調節反応


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Title: X線照射による視床下部障害ウサギの体温調節反応
Other Titles: Thermoregulatory Responses of Rabbits Impairing Pre-optic Hypothalamus by X-ray Irradiation
Authors: 大渡, 伸 / 藤原, 真理子 / 小坂, 光男
Authors (alternative): Ohwatari, Nobu / Fujiwara, Mariko / Kosaka, Mitsuo
Issue Date: 30-Jun-1983
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 25(2). p107-111, 1983
Abstract: X線多門照射による視床下部障害ウサギを用いて,暑熱刺激で誘発される末梢血管拡張や温熱性浅速呼吸(panting)などの熱放散反応について検索した。視床下部障害ウサギの熱放散反応は,正常ウサギのそれと酷似であった。両群ウサギの末梢血管拡張には差を認めなかったが,pantingによる熱放散能は視床下部障害ウサギが正常ウサギより僅かに劣っていた。視床下部障害ウサギを暑熱・寒冷に順化して上記の諸反応を比較したところ,(1)直腸温については寒冷順化ウサギより暑熱順化ウサギの方が高いレベルに調節されていた,(2)熱放散反応量に関しては暑熱順化ウサギは,寒冷順化ウサギより大きく,これは,暑熱・寒冷順化した視床下部無傷ウサギの結果と酷似であった。これらの結果は,温度順化や体温調節反応系が,中枢神経幹内の温度感受性組織に局在する階層状調節機構によって形成される事を示唆している。 / The time courses of the changes in peripheral vasodilation and in thermal panting induced by general heat exposure in unanesthetized PO/AH impaired rabbits closely resemble those observed in intact rabbits, although heat loss capability was slightly reduced. In the heat-acclimated PO/AH impaired rabbits, the level at which rectal temperature was regulated was higher than that in the cold-acclimated PO/AH impaired animals. The present findings that gains of heat dissipation to general heating increased in the heat-acclimated PO/AH impaired rabbits compared with these in the cold-acclimated PO/AH impaired rabbits were similar to those reported in thermally acclimated PO/AH intact rabbits. These results suggest that the thermal acclimation and temperature regulation system must be composed of hierarchically organized control loops located in thermosensitive tissues of central nervous axis.
URI: http://hdl.handle.net/10069/4354
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 25, No. 2

Citable URI : http://hdl.handle.net/10069/4354

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