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スナネズミに感染させたBrugia pahangiの仔虫に対するジエチルカルバマジンの治療効果


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Title: スナネズミに感染させたBrugia pahangiの仔虫に対するジエチルカルバマジンの治療効果
Other Titles: The Effect of Diethylcarbamazine on Microfilariae of Brugia pahangi in Mongolian Jirds (Meriones unguiculatus)
Authors: 山下, 征二 / 重野, 鎮義 / 木村, 英作 / 青木, 克己
Authors (alternative): Yamashita, Seiji / Shigeno, Shizugi / Kimura, Eisaku / Aoki, Yoshiki
Issue Date: 30-Sep-1983
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 25(3). p113-117, 1983
Abstract: ジエチルカルバマジン(DEC)を,スナネズミ体重1kg当り300mg宛,腹腔内に1日1回,5日間連続投与した場合,或は,同量のDECを43日間にわたり2日おきに15回投与した場合,スナネズミ血液中のB. pahangi仔虫数に明らかな減少を認めた. DECの15回投与は,5回投与に比し,その効果はより強く持続的で,薬量依存の傾向がみられた.胃内挿管法によりDEC 300mg/kgを8回投与した場合の治療効果は,前2者に比べて劣ることが観察された. / Diethylcarbamazine (DEC) was effective in reducing microfilarial densities of Brugia pahangi in Mongolian jirds (Meriones unguiculatus) when it was administered intraperitoneally at the daily dosage of 300 mg/kg of body weight either for 5 consecutive days or every 3 days for 43 days with the total of 15 doses. The latter treatment scheme seemed to be more effective than the former, suggesting that the effect was dose-dependent. The DEC treatment by stomach intubation seemed to be less effective than the intraperitoneal administration of the medicine.
URI: http://hdl.handle.net/10069/4355
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 25, No. 3

Citable URI : http://hdl.handle.net/10069/4355

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