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NAOSITE : Nagasaki University's Academic Output SITE > Institute of Tropical Medicine > Bulletin > Tropical medicine > Volume 26, No. 4 >

ウサギ静脈内及び側脳室内へのLPS pyrogen投与による発熱曲線の解析

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Title: ウサギ静脈内及び側脳室内へのLPS pyrogen投与による発熱曲線の解析
Other Titles: An Analysis of Fever-curves due to the Intravenous vs. Intraventricular Administration of LPS Pyrogen in Rabbits
Authors: 藤原, 真理子 / 范, 育仁 / 小坂, 光男 / Ye-Win
Authors (alternative): Fujiwara, Mariko / Fan, Yu-Jen / Ye-Win / Kosaka, Mitsuo
Issue Date: 28-Dec-1984
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 26(4). p187-190, 1984
Abstract: 大腸菌由来のlipopolysaccharide (LPS)を用いて,ウサギの発熱曲線の解折を行った.ウサギに体重1kgあたり0.2μgのLPS pyrogenを耳介皮膚血管から静脈内投与すると,10分から30分の短い潜時ののちに,二峰性の発熱が観察された.ところが,同濃度のpyrogenの側脳室への直接注入では,約1時間の潜時で,直腸温の上昇も1.5℃から2.0℃と,pyrogen静注時に比較すると高い一峰性の発熱が生じた.投与部位の差異による発熱パターンの違いから,LPS pyrogenの作用部位とその働きについて考察を加えた. / Fever-curves were compared on response to injection of bacterial pyrogen into conscious rabbits using different routes of administration. Intravenous application of 0.2μg/kg LPS pyrogen to the rabbit was characterized by biphasic fever after a short delay of 10 to 30 minutes. However, monophasic fever developed when same dosage of LPS was administrated into the lateral-ventricular region. Its latency of fever onset was about 60 minutes with rectal temperature elevating by 1.5 to 2.0℃, and these febrile states continued for more than 5 hours. Based on these results, sites of pyrogen action and their underlying mechanisms were discussed in this paper.
URI: http://hdl.handle.net/10069/4394
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 26, No. 4

Citable URI : http://hdl.handle.net/10069/4394

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