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スナネズミ(Meriones unguiculatus)を用いたマンソン住血吸虫症の研究 : 再感染に対する抵抗性


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Title: スナネズミ(Meriones unguiculatus)を用いたマンソン住血吸虫症の研究 : 再感染に対する抵抗性
Other Titles: Defect of Resistance of Jird (Meriones unguiculatus) to Reinfection of Schistosoma mansoni and its Development after Treatment
Authors: Francois, Aoussi Eba / 嶋田, 雅暁 / 佐藤, 克之 / 勝又, 達也 / Swarto / 青木, 克己
Authors (alternative): Shimada, Masaaki / Sato, Katsuyuki / Katsumata, Tatsuya / Suwarto / Aoki, Yoshiki
Issue Date: 30-Sep-1985
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 27(3). p155-163, 1985
Abstract: スナネズミのマンソン住血吸虫に対する再感染抵抗性を肺からschistosomulaを回収する方法で観察した.初感染から8,12,16週後にchallenge infectionを行った結果,いずれの時期でも既感染群と初感染群(対照群)の間で肺からのschistosomulaの回収率に差はなかった.しかし感染後8週目にpraziquantelで治療すると,不完全に治療した群では対照群との差はないものの,完全治療群では再感染に対する抵抗性の発現が見られた.スナネズミはマンソン住血吸虫に対して通常は再感染抵抗性を示さない動物モデルとして有用と考えられる. / Resistance to reinfection after primary infection with Schistosoma mansoni was examined by the recovery technique of schistosomula from lungs in jirds (Meriones unguiculatus). After 8, 12 and 16 weeks of primary infection, no resistance was observed when the recovery rate of schistosomula from reinfected group was compared with that of previously uninfected group. Effective treatment of jirds with eight-week old patent infections with praziquantel resulted in slight development of resistance to the challenge when their recovery rate of schistosomula was compared with that of the primarily infected jirds. There was no difference in the recovery rate between infected jirds with incomplete treatment and previously uninfected jirds. Jird is a convenient animal model which does not develop resistance to reinfection with S. mansoni.
URI: http://hdl.handle.net/10069/4415
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 27, No. 3

Citable URI : http://hdl.handle.net/10069/4415

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