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視床下部破壊ウサギの体温調節能に関する研究


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Title: 視床下部破壊ウサギの体温調節能に関する研究
Other Titles: Studies on Thermoregulatory Capability in the PO/AH Lesioned Rabbit
Authors: Ye-Win / 小坂, 光男 / 大渡, 伸 / 藤原, 真理子 / 土屋, 勝彦 / 岩元, 純 / 范, 育仁
Authors (alternative): Ye-Win / Kosaka, Mitsuo / Ohwatari, Nobu / Fujiwara, Mariko / Tsuchiya, Katsuhiko / Iwamoto, Jun / Fan, Yu-Jen
Issue Date: 30-Sep-1985
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 27(3). p171-179, 1985
Abstract: 両側視床下部破壊ウサギに環境温度刺激(25℃→40℃→10℃→25℃)を加えて誘発される体温調節反応から体温調節機序の解明を試みた.前視床下部(PO/AH)の破壊には直流を用い,破壊後の体温調節能の推移を検索した.無傷ウサギの耳介皮膚温度変化は環境温度変化と同じ方向に推移し,その直腸温度変化は微少であった.PO/AH破壊1週間後のウサギの直腸温は加温刺激時で大きく変動をみたが,冷却刺激には,かなりの抵抗を示した.破壊2週間後には,環境温度刺激に対する直腸温変化は無傷ウサギの直腸温変化に近似となった.この実験結果はPO/AH破壊ウサギの体温調節能には回復がみられる事を示唆しており,視床下部外温度感受性組織(脳幹や脊髄)による体温調節機能の修飾が推察される. / In the present series of experiments, we tried to elucidate the nature of thermoregulation in responses to environmental temperature shifts (25℃→40℃→10℃→25℃) in the rabbits devoid of pre-optic and anterior hypothalamic (PO/AH) regions. Bilateral PO/AH lesions in male rabbits were accomplished using electrolytic procedure. And thermoregulatory capabilities before and after PO/AH lesions were compared. In control rabbits, with the change in ambient temperature (Ta), the ear skin temperature (Tea) changed in the same direction. The change in rectal temperature (Tre) was small. In one-week-lesioned rabbit, the change of Tre was great when heated, but Tre was stable to cold stress. In two-weeks lesioned rabbit, Tre, inspite of Ta change, was quite stable: to the extent that it was comparable to the control rabbits. Therefore, these results should be interpreted as presenting the recovery of thermoregulatory functions after the PO/AH lesions. It is concluded that, without PO/AH participation, extrahypothalamic thermosensitive tissues were the places endowed with these thermoregulatory functions.
URI: http://hdl.handle.net/10069/4417
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 27, No. 3

Citable URI : http://hdl.handle.net/10069/4417

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