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NAOSITE : Nagasaki University's Academic Output SITE > Institute of Tropical Medicine > Bulletin > Tropical medicine > Volume 27, No. 4 >

Diethylcarbamazine治療前後に於けるDirofilaria immitisミクロフィラリアのマウス体内での分布の差異について


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Title: Diethylcarbamazine治療前後に於けるDirofilaria immitisミクロフィラリアのマウス体内での分布の差異について
Other Titles: Mobilization of Dirofilaria immitis Microfilariae in Mice during the Treatment with Diethylcarbamazine
Authors: 坂本, 信 / 佐藤, 克之 / 青木, 克己 / 立花, 保行 / Trangay, Aracely Lujan
Authors (alternative): Sakamoto, Makoto / Sato, Katsuyuki / Aoki, Yoshiki / Tachibana, Yasuyuki / Trangay, Aracely Lujan
Issue Date: 28-Dec-1985
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 27(4). p191-196, 1985
Abstract: Dirofilaria immitisミクロフィラリア30,000隻をICRマウスの鼠径部皮下に接種し,Diethylcarbamazine(DEC)300mg/kg治療によるミクロフィラリアのマウス体内での分布の変動を観察した.DEC投与前の平均仔虫回収率は35.4%で,投与後3日目には21.1%に減少した.仔虫の体内での分布はDEC投与によりPeltよりCarcass, Visceraに移動する傾向がみられ,特に内臓では肝臓,腎臓,脾臓,肺臓,腸間膜等に仔虫が多くみられ,心臓では仔虫の減少が観察された. / The provocative activity of diethylcarbamazine (DEC) on the skin-dwelling microfilariae was examinend by using a mouse-Dirofilaria immitis microfilariae model. The mice were inoculated subcutaneously with 30,000 D. immitis microfilariae and given DEC at dosage of 300mg/kg body weight on 3,4 and 5 days after inoculation. Ten animals treated with DEC and ten control animals were necropsied on the 6 th day after infection in order to recover microfiariae alive. DEC treatment induced the reduction in the total number of microfilariae recovered from a mouse. The remarkable reduction was recognized in the number of microfilariae from pelt (p<0.001). On the contrary, the number of microfilariae from viscera was likely to increase, though the difference was not statistically significant. These facts suggested that DEC might cause the mobilization of microfilariae into viscera, especially to liver and kidneys. The possible invasion of large number of D. immitis microfilariae into deep organs during the treatment was discussed.
URI: http://hdl.handle.net/10069/4419
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 27, No. 4

Citable URI : http://hdl.handle.net/10069/4419

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