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プロスタグランディソE1発熱におけるトラゾリンの効果に関する研究


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Title: プロスタグランディソE1発熱におけるトラゾリンの効果に関する研究
Other Titles: The Effect of Intraventricular Injection of Tolazoline on PGE_1 -Induced Fever in the Rabbit
Authors: 岩元, 純
Authors (alternative): Iwamoto, Jun
Issue Date: 31-Mar-1986
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 28(1). p1-14, 1986
Abstract: 無麻酔下の雄の家兎について,側脳室留置カテーテルにより種々の薬剤を投与し,発熱及び解熱過程における効果器活動を測定した.プロスタグラディンE_1(PGE_1)によって惹起された耳介皮膚温(Tea)の低下と呼吸数(RF)の低下は,前投与されたαブロッカーであるトラゾリン(Tol)によって抑制されたが,後投与されたTolからは抑制をうけず,むしろPGE_1による効果器活動を促進した.スルピリン(Dip)はこれらの反応を抑制した.また,ノルアドレナリン(NA)はTeaの低下を惹起したが, RFに対しては著明な反応を示さなかった.このNAによるTeaの低下に対して, Dipは抑制的に働きTeaの上昇を促した.非選択的αブロッカーであり, 5HTのブロッカーでもあるTolは,単独投与でもTeaの低下を惹起した. Tolの相反する2種類の作用は,それが抑制するレセプターの相違によって生じるものと思われるが,文献的考察も加えると, PGE_1と前投与したTolの作用部位はおそらく前シナプス性のα_2-レセプターではないかと推察される.又,後投与したTolの作用部位は冷信号伝搬に関係した細胞の後シナプス性のレセプター(抑制性)ではないかと思われる. / The interactions of prostaglandin E_1 (PGE_1) and tolazoline, as well as noradrenaline (NA) and dipyron on fever induction were studied in rabbits through intraventricular microinjection technique. Monitorings of febrile responses were made on rectal temperature, ear skin temperature and respiratory frequency. Pre-injected tolazoline, an alphaadrenoceptor blockade diminished febrile responses elicited by PGE_1, whereas post-in-jected tolazoline didn't induce any antagonistic effects on PGEi-fever, rather it facilitated febrile responses, especially drop of ear skin temperature, or in a few cases it induced shivering. Tolazoilne is the antagonist of both alpha 1-and alpha 2-adrenoceptors and also the weak antagonist for 5-hydroxytryptamine (5-HT). So it is assumed that post-injected tolazoline may not act on the receptor sites on which PGE_1 has already occupied and would inhibit other receptors which are responsible for the antagonism of fever induction ie the facilitation of warm responsive units or the inhibition of cold responsive units. An antipyretic drug dipyron was antagonistic to all the responses elicited by PGE_1 and NA. It also depressed febrile responses exaggerated by tolazoline. Considering the presynaptic inhibitory modulation of PGE_1, the results would permit us to conclude that PGE_1 may act on presynaptic alpha 2-adrenoceptor which modulate synaptic transmission onto cold responsive units, and the effect of dipyron might be involved in such synaptic transmission.
URI: http://hdl.handle.net/10069/4432
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 28, No. 1

Citable URI : http://hdl.handle.net/10069/4432

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