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オリゴヌクレオチドフィンガープリント法による日本脳炎(JE)ウイルスの分子疫学的研究


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Title: オリゴヌクレオチドフィンガープリント法による日本脳炎(JE)ウイルスの分子疫学的研究
Other Titles: Oligonucleotide Fingerprint Analysis on Japanese Encephalitis (JE) Virus Strains of Different Geographic Origins
Authors: 堀, 博之
Authors (alternative): Hori, Hiroyuki
Issue Date: 30-Sep-1986
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 28(3). p179-190, 1986
Abstract: Genetic variation in Japanese encephalitis virus isolates from various geographic areas was examined by oligonucleotide fingerprint of the 42S genome RNA. Isolates in the same geographic areas and in the same years were very similar but differed from those in other areas or in different years in the same areas. Japanese isolates were rather similar to each other and similarity between strains was greater as the years of isolations were closer. Recent isolates from Thailand and Vietnam were similar to each other, however, they were quite different from Japanese isolates. Two Taiwan isolates in 1981 with high similarity to each other were also quite different from Thai and Vietnamese isolates, although one of them showed relative closeness to recent Japanese isolates. From these results, it was presumed that mutations and selections of JE virus genome would have progressed independently in geographically distant areas. Nakayama (Japan, 1935) and Peking-1 (China, 1949) strains were rather similar, suggesting that early Japanese strains may have some relationships to early Chinese strains.
URI: http://hdl.handle.net/10069/4449
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 28, No. 3

Citable URI : http://hdl.handle.net/10069/4449

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