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慢性視床下部障害ウサギの体温調節能の回復過程に関する研究


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Title: 慢性視床下部障害ウサギの体温調節能の回復過程に関する研究
Other Titles: Recovery of Thermoregulatory Function in Chronic Rabbit with Preoptic Area and Anterior Hypothalamic Lesions
Authors: 大渡, 伸
Authors (alternative): Ohwatari, Nobu
Issue Date: 30-Sep-1986
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 28(3). p225-240, 1986
Abstract: 22羽のウサギの視束前野・前視床下部(PO/AH)を電気破壊して,破壊後1日目・3日目・7日目・14日目・28日目に,36℃から10℃の連続した全身皮膚温度刺激を加え,体温調節能を検索し,破壊前値と比較検討した.典型的なPO/AH破壊が認められた6羽について,休温調節能の回復過程を解析し,下記の結果を得た.(1)PO/AH破壊により,食物摂取量は減少し,体重は7日目まで有意に減少した.以後,食物摂取量の増加に伴い,体重は徐々に増加した.(2)PO/AH破壊後1日目の25℃における安静時の直腸温は,破壊前の値に比し有意に高かった.(3)PO/AH破壊により,耳介の皮膚血管拡張や浅速呼吸による熱放散能力が障害を受け,暑熱暴露に対し直腸温は有意に上昇した.しかし,熱放散能力は徐々に回復し,破壊後28日目には,直腸温の上昇は破壊前値に比し有意の差は認められなかった.(4)PO/AH破壊により,耳介の皮膚血管収縮による熱放散抑制能力は障害を受けず,寒冷暴露に対し直腸温は僅かに下降した.PO/AH破壊により,暑熱に対する体温調節能は一過性の障害がみられたが,この機能障害は1ケ月後回復した.その回復は,後視床下部・中脳・延髄・脊髄などPO/AH以外の温度感受性組織と,これ等組織の統合機能の関与が,増大してきた結果と考えられる. / The thermoregulatory responses to the continuous general thermal stimulation between 36℃ and 10℃ were observed in Six rabbits with bilateral preptic area and anterior hypothalamus (PO/AH) lesions by electrolytic destruction. Series of experiments were performed on each rabbit, once before and five times after the operation of PO/AH lesions, and thermoregulatory ability in recovering process was investigated in rabbits with PO/AH lesions. (1) The body weights significantly decreased after PO/AH operation. But food intake (g/day) recovered to normal level at the 7th day after PO/AH operation and the body weights were over the preoperational level at the 18th day after PO/AH operation. (2) The PO/AH lesion caused marked impairment of abilities in heat loss responses such as vasodilation and thermal panting which lasted for 7 days after surgical operation. Therefore, general hyperthermia was successively induced, and rectal temperature (Tre) increased significantly in heat exposure. (3) Heat loss ability gradually recovered to the normal level by the 28th day after PO/AH operation, and Tre was controlled within normal range when the animal was exposed to heat exposure. (4) On the other hand, PO/AH lesion caused scarcely any disturbance of heat conservative function such as vasoconstriction. Therefore, no significant decrease in Tre was observed in PO/AH lesion rabbits, even in cold exposure. These results suggest that extra PO/AH thermosensitive tissues in the posterior hypothalamus, midbrain reticular formation, medulla oblongata and spinal cord may join to play an important role of thermoregulation to general thermal stimulation within 28 days after bilateral PO/AH destruction in rabbits.
URI: http://hdl.handle.net/10069/4453
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 28, No. 3

Citable URI : http://hdl.handle.net/10069/4453

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