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The Uptake of 5-Hydroxytryptamine by Litomosoides carinii and the Effect of Antifilarials


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Title: The Uptake of 5-Hydroxytryptamine by Litomosoides carinii and the Effect of Antifilarials
Authors: Saxena, J. K. / Sen, Ramanuj / Chatterjee, R. K. / Ghatak, S.
Issue Date: 28-Dec-1987
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 29(4). p221-230, 1987
Abstract: Litomosoides carinii, the filarial parasite of cotton rat (Sigmodon hispidus), has been shown to possess both high and low affinity uptake mechanisms for 5-hydroxytryp-tamine (5-HT). The Michaelis-Menten constant (K_m) and Vmax values for high affinity system were 1.9 μM and 1.25 μM/g/2 min, while the corresponding values for the low affinity system were 10 μM and 6.6 μM/g/2 min respectively. The uptake mechanism was found to be temperature dependent and was inhibited by microfilaricides-diethylcar-bamazine and centperazine, the latter exhibiting more pronounced effect. The filarial worms could not synthesize 5-HT from its precursor amino acid, tryptophan.
URI: http://hdl.handle.net/10069/4506
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 29, No. 4

Citable URI : http://hdl.handle.net/10069/4506

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