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Induction of Experimental Protoporphyria in Hairless Mice by Griseofulvin


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Title: Induction of Experimental Protoporphyria in Hairless Mice by Griseofulvin
Authors: Yamashita, Kazunori / Nonaka, Shigeo / Murayama, Fumio / Ohgami, Taro / Nagato, Nori / Irifune, Hiroko / Watanabe, Masahisa / Yoshida, Hikotaro
Issue Date: 30-Sep-1988
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 30(3). p219-224, 1988
Abstract: To investigate whether or not protoporphyria can be induced in hairless mice, feed containing 0.5% griseofulvin (GF) was given to hairless Hos^<[○!R]> HR/De strain mice for two to four months. Administration of GF caused protoporphyria in the hairless mice, that is, protoporphyrin levels in the erythrocytes and the liver were extremely elevated. Acute skin changes such as erythema, edema, blister and crust formation were produced by exposing the hairless mice with protoporphyria to 400 nm of light using the metal halide lamp. From these results, we confirmed that hairless mice of HR/De strain can be utilized as a model for protoporphyria. These mice are useful for macroscopic and histopathological observations of skin changes and are also convenient for photosensitivity experiments.
URI: http://hdl.handle.net/10069/4531
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 30, No. 3

Citable URI : http://hdl.handle.net/10069/4531

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