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Induction of Experimental Protoporphyria in Hairless Mice by Griseofulvin

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タイトル: Induction of Experimental Protoporphyria in Hairless Mice by Griseofulvin
著者: Yamashita, Kazunori / Nonaka, Shigeo / Murayama, Fumio / Ohgami, Taro / Nagato, Nori / Irifune, Hiroko / Watanabe, Masahisa / Yoshida, Hikotaro
発行日: 1988年 9月30日
出版者: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
引用: 熱帯医学 Tropical medicine 30(3). p219-224, 1988
抄録: To investigate whether or not protoporphyria can be induced in hairless mice, feed containing 0.5% griseofulvin (GF) was given to hairless Hos^<[○!R]> HR/De strain mice for two to four months. Administration of GF caused protoporphyria in the hairless mice, that is, protoporphyrin levels in the erythrocytes and the liver were extremely elevated. Acute skin changes such as erythema, edema, blister and crust formation were produced by exposing the hairless mice with protoporphyria to 400 nm of light using the metal halide lamp. From these results, we confirmed that hairless mice of HR/De strain can be utilized as a model for protoporphyria. These mice are useful for macroscopic and histopathological observations of skin changes and are also convenient for photosensitivity experiments.
URI: http://hdl.handle.net/10069/4531
ISSN: 03855643
資料タイプ: Departmental Bulletin Paper
出現コレクション:第30巻 第3号

引用URI : http://hdl.handle.net/10069/4531



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