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Influence of Mannose and Its Derivatives on the Growth of Trypanosoma brucei gambiense in vitro


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Title: Influence of Mannose and Its Derivatives on the Growth of Trypanosoma brucei gambiense in vitro
Authors: Mhando, Peter J. / Fukuma, Toshihide / Uemura, Haruki / Sooksri, Varunee / Kanbara, Hiroji
Issue Date: 28-Dec-1988
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 30(4). p251-256, 1988
Abstract: In the previous experiment mannose specifically inhibited the growth of blood trypomastigotes of Trypanosoma brucei gambiense in vitro over new born mouse brain cells. On the search of its mode of action, effect of mannose derivatives and other monosaccharides on the growth of trypanosomes both on feeder layer and feeder layer free systems was assayed. Different concentrations of each of the monosaccharides and mannose derivatives were added into culture media and used for the cultivation of trypanosomes. Most of the monosaccharides and mannose derivatives tested had no pronounced effect on the growth of the parasites, except α-D-(+)-mannose and 2-Deoxy-D-glucose which specifically inhibited the growth of bloodstream forms on feeder layer and feeder layer free cultures. Furthermore, transmission electron microscopy revealed denaturation of glycosomes, nuclei and kinetoplasts in those parasites cultured in medium containing α-D-(+)-mannose or 2-Deoxy-D-glucose. Nevertheless, surface coat, cell membrane and subpellicular microtubules were intact. Possible mode of action of mannose and 2-Deoxy-D-glucose is discussed.
URI: http://hdl.handle.net/10069/4536
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 30, No. 4

Citable URI : http://hdl.handle.net/10069/4536

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