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Mechanisms of Acquired Immunity against Brugia pahangi : Inflammatory Cell Responses and Antibody Formation Following the Challenge Infection in Mice Immunized with Naive Infective Larvae


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Title: Mechanisms of Acquired Immunity against Brugia pahangi : Inflammatory Cell Responses and Antibody Formation Following the Challenge Infection in Mice Immunized with Naive Infective Larvae
Authors: Nakanishi, Hirokuni / Horii, Yoichiro / Terashima, Kenjiro / Fujita, Koichiro
Issue Date: 31-Mar-1989
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 31(1). p25-34, 1989
Abstract: The mechanisms of resistance of immunized BALB/c mice to intraperitoneally challenged B. pahangi were examined. Mice developed significant resistance to challenge infection by immunization with naive B. pahangi infective larvae. Remarkable resistance was already established at 5 weeks after immunization and persisted at least until 12 weeks. Resistance in immunized mice appeared at the early phase of challenge infection (5 days post-inoculation) and became more remarkable on day 10 and 15 post-inoculation. Immunized mice showed higher inflammatory cell (lymphocytes, macrophages and eosinophils) responses against B. pahangi challenge infection than control mice at 5 and 10 days post-infection. At that time, immunized mice showed high levels of anti-B. pahangi IgG and IgM antibodies. Moreover, many killed or weakened larvae encapsulated with inflammatory cells (macrophages and eosinophils were predominant) were observed in the peritoneal cavities of immunized mice. These results suggest that the significant resistance to challenge infection in mice immunized by naive B. pahangi infective larvae is due to developed inflammatory cell responses and coexistence of specific antibodies.
URI: http://hdl.handle.net/10069/4541
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 31, No. 1

Citable URI : http://hdl.handle.net/10069/4541

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